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Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009].. Additionally we are shipping Dehydrogenase/reductase (SDR Family) Member 7 Antibodies (66) and many more products for this protein.
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Data suggest that (1) cortisone is a substrate of DHRS7 and is reduced to 20beta-dihydrocortisone, (2) androstenedione is not a relevant substrate of DHRS7, (3) DHRS7 catalyzes the oxidoreduction of 5alpha-dihydrotestosterone to 3alpha-androstanediol with a suppressive effect on androgen receptor (show AR Proteins) transcriptional activity, and (4) DHRS7 is anchored in endoplasmic reticulum membrane with cytoplasmic orientation.
DHRS7 participates in the reductive metabolism of steroids and retinoids.Expression patterns of DHRS7 at the mRNA as well as protein level were determined in a panel of various human tissue samples.
DHRS7 containing TEV-cleavable His10 and FLAG-tag was cloned and expressed in the Sf9 cell line.
DHRS7 is another enzyme from SDR (show SDPR Proteins) superfamily that have been proved, at least in vitro, to contribute to the metabolism of xenobiotics with carbonyl group.
Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000
Down-regulated in nephrectomized rat kidney 3
, dehydrogenase/reductase (SDR family) member 7
, dehydrogenase/reductase SDR family member 7
, retinal short-chain dehydrogenase/reductase 4
, short chain dehydrogenase/reductase family 34C, member 1