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DAZ1 is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Additionally we are shipping DAZ1 Antibodies (53) and many more products for this protein.
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We investigated partial deletion of AZFc region and DAZ copy number in a population of Iranian infertile men and normozoospermic controls.
Susceptibility of gr/gr (show GSR Proteins) rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 (show CDY2A Proteins) gene copy deletions.
Overexpression of DAZ1 is associated with breast tumors.
Studies indicate that partial RNA-binding proteins DAZ1/2 deletion was associated wih male infertility, but partial RNA-binding proteins DAZ3 (show DAZ3 Proteins)/4 deletion was not associated with male infertility.
We did not found any statistically significant genetic association between DAZ alleles and idiopathic male infertility
genetic association study in Chinese population: Data suggest that combined patterns of copy number abnormality in DAZ1 (deleted in azoospermia 1) and/or BPY2 (basic charge Y-linked protein 2) are associated with spermatogenic impairment/azoospermia.
There appears to be an asociation of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.
genetic association studies in Han population in China: Data suggest that AZF1/DAZ1 duplications underlie genetic predisposition of Y-chromosome haplogroup K* to spermatogenic impairment (azoospermia/oligospermia) in the population studied.
The methylation patterns of CpG island (CGI) in the DAZ gene promoter region were different between somatic cells and spermatic cells
DAZ gene copy number in severely idiopathic infertile men. Gene deletion of two copies of DAZ (DAZI and 2) was the cause of spermatogenic damage.
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications\; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat\; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified\; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described\; thus the RefSeq for this gene contains only two RRM domains.
deleted in azoospermia 1
, DAZ protein
, deleted in azoospermia 4
, deleted in azoospermia protein 1