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Differentially Expressed in FDCP 6 Homolog (Mouse) Proteins (DEF6)

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Additionally we are shipping DEF6 Antibodies (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DEF6 23853 Q8C2K1
DEF6 50619 Q9H4E7
Rat DEF6 DEF6 309642  
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Top DEF6 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DEF6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Interaction Partners

Zebrafish Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. Swap70b and Def6a delineate Wnt11 (show WNT11 Proteins) and Wnt5b (show WNT5B Proteins) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation

  2. def6 morphants phenocopy Wnt5b (show WNT5B Proteins) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (show WNT5B Proteins) morphants, indicating a novel role for def6 as a central GEF (show SLC2A4RG Proteins) downstream of Wnt5b (show WNT5B Proteins) signaling

Mouse (Murine) Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.

  2. SLAT is an IP3R1 (show ITPR1 Proteins)-interacting protein required for T cell activation.

  3. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.

  4. Data suggest that SLAT acts as a negative modulator of RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis.

  5. SLAT-mediated nuclear factor of activated T-cell (show NFATC3 Proteins) (NFAT)1 (show NFAT1 Proteins) activation is required for efficient expansion of CD8 (show CD8A Proteins)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.

  6. SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.

  7. plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (show ZAP70 Proteins) signaling

  8. tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT (show NFATC1 Proteins)-dependent CD4 (show CD4 Proteins)(+) T cell differentiation.

  9. IRF-4-binding protein sequestered IRF-4 (show IRF4 Proteins) and prevented it from targeting the transcriptional regulatory regions of the genes that encode IL-17 (show IL17A Proteins) and IL-21 (show IL21 Proteins).

  10. IBP/Def6 as a novel component of the TLR4 (show TLR4 Proteins)-induced signaling cascade that controls the production of proinflammatory cytokines

Human Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. IBP (show TSPO Proteins) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases

  2. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.

  3. Molecular cloning of IBP (show TSPO Proteins), a guanine nucleotide exchange factor (show RASGRF1 Proteins), which is highly expressed in the immune system.

  4. IBP (show TSPO Proteins) is a novel guanine nucleotide exchange factor (show RASGRF1 Proteins) and is recruited to the immunological synapse by T cell receptor engagement

  5. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function

  6. Overexpression of the Interferon regulatory factor 4 (show IRF4 Proteins)-binding protein is associated with Colorectal Carcinoma.

  7. DEF6 (show DEFA6 Proteins), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (show CDC42 Proteins), and RhoA (show RHOA Proteins).

DEF6 Protein Profile

Protein Summary

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003

Gene names and symbols associated with DEF6

  • differentially expressed in FDCP 6 homolog (mouse) (DEF6)
  • differentially expressed in FDCP 6a homolog (mouse) (def6a)
  • differentially expressed in FDCP 6 homolog (def6)
  • differentially expressed in FDCP 6 homolog (LOC100498543)
  • differentially expressed in FDCP 6 (Def6)
  • differentially expressed in FDCP 6 homolog (mouse) (Def6)
  • 2410003F05Rik protein
  • 6430538D02Rik protein
  • AV094905 protein
  • Def6 protein
  • IBP protein
  • MGC68775 protein
  • SLAT protein
  • Slat2 protein
  • Slat6 protein
  • SWAP70L protein
  • zgc:63721 protein

Protein level used designations for DEF6

differentially expressed in FDCP 6 homolog (mouse) , differentially expressed in FDCP 6 homolog , DEF-6 , IRF-4-binding protein , IRF4-binding protein , SWAP-70-like adapter of T-cells , SWAP-70-like adaptor protein of T cells

GENE ID SPECIES
419893 Gallus gallus
462636 Pan troglodytes
394015 Danio rerio
398924 Xenopus laevis
100498543 Xenopus (Silurana) tropicalis
100053351 Equus caballus
23853 Mus musculus
50619 Homo sapiens
608163 Canis lupus familiaris
100154998 Sus scrofa
516457 Bos taurus
309642 Rattus norvegicus
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