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DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Additionally we are shipping DEF6 Antibodies (64) and many more products for this protein.
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Swap70b and Def6a delineate Wnt11 (show WNT11 Proteins) and Wnt5b (show WNT5B Proteins) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
def6 morphants phenocopy Wnt5b (show WNT5B Proteins) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (show WNT5B Proteins) morphants, indicating a novel role for def6 as a central GEF (show SLC2A4RG Proteins) downstream of Wnt5b (show WNT5B Proteins) signaling
These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
SLAT is an IP3R1 (show ITPR1 Proteins)-interacting protein required for T cell activation.
PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.
Data suggest that SLAT acts as a negative modulator of RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis.
SLAT-mediated nuclear factor of activated T-cell (show NFATC3 Proteins) (NFAT)1 (show NFAT1 Proteins) activation is required for efficient expansion of CD8 (show CD8A Proteins)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.
SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.
plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (show ZAP70 Proteins) signaling
tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT (show NFATC1 Proteins)-dependent CD4 (show CD4 Proteins)(+) T cell differentiation.
IRF-4-binding protein sequestered IRF-4 (show IRF4 Proteins) and prevented it from targeting the transcriptional regulatory regions of the genes that encode IL-17 (show IL17A Proteins) and IL-21 (show IL21 Proteins).
IBP/Def6 as a novel component of the TLR4 (show TLR4 Proteins)-induced signaling cascade that controls the production of proinflammatory cytokines
IBP (show TSPO Proteins) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases
DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.
Molecular cloning of IBP (show TSPO Proteins), a guanine nucleotide exchange factor (show RASGRF1 Proteins), which is highly expressed in the immune system.
IBP (show TSPO Proteins) is a novel guanine nucleotide exchange factor (show RASGRF1 Proteins) and is recruited to the immunological synapse by T cell receptor engagement
DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function
Overexpression of the Interferon regulatory factor 4 (show IRF4 Proteins)-binding protein is associated with Colorectal Carcinoma.
DEF6 (show DEFA6 Proteins), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (show CDC42 Proteins), and RhoA (show RHOA Proteins).
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003
differentially expressed in FDCP 6 homolog (mouse)
, differentially expressed in FDCP 6 homolog
, IRF-4-binding protein
, IRF4-binding protein
, SWAP-70-like adapter of T-cells
, SWAP-70-like adaptor protein of T cells