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DAB2 encodes a mitogen-responsive phosphoprotein. Additionally we are shipping DAB2 Proteins (7) and DAB2 Kits (4) and many more products for this protein.
Showing 10 out of 84 products:
Mouse (Murine) Polyclonal DAB2 Primary Antibody for WB - ABIN1881248
Collaco, Jakab, Hegan, Mooseker, Ameen: Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. in The Journal of biological chemistry 2010
Show all 5 references for ABIN1881248
Human Polyclonal DAB2 Primary Antibody for FACS, IHC (p) - ABIN652936
Tseng, Ely, Pong, Wang, Zhou, Hsieh: The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer. in The Journal of biological chemistry 1999
these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages
inhibition of WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart.
DAB2 regulated the cell migration associated genes in PC3 (show PCSK1 Antibodies) cells, and the differential DAB2 expression between LNCaP and PC3 (show PCSK1 Antibodies) cells was partly regulated by histone 4 acetylation.
Dab2 depletion also increases the rescued protein half-life of DeltaF508 CFTR (show CFTR Antibodies) by ~18% and ~91%, respectively
These results indicated that miR (show MLXIP Antibodies)-93 plays an important role in the initiation and progression of NPC (show NPC1 Antibodies) by targeting Dab2 and the miR (show MLXIP Antibodies)-93/Dab2 pathway may contribute to the development of novel therapeutic strategies for NPC (show NPC1 Antibodies) in the future.
DAB2 expression is decreased in Non-Small Cell Lung Cancer , and the frequent methylation event at sites -86 to 226 of the DAB2 gene could contribute to the downregulation of DAB2.
Attenuating Dab2 expression in K562 cells diminished TfR (show TFRC Antibodies) internalization and increased surface levels of TfR (show TFRC Antibodies) concomitantly with a decrease in Tf uptake and erythroid differentiation.
Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis
Numb (show NUMB Antibodies) specifically regulates NPC1L1 (show NPC1L1 Antibodies)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH (show LDLRAP1 Antibodies) and Dab2, which selectively participate in LDLR (show LDLR Antibodies)-mediated LDL uptake.
Akt1 (show AKT1 Antibodies) and Akt2 (show AKT2 Antibodies) are involved in albumin (show ALB Antibodies) endocytosis, and phosphorylation of Dab2 by Akt (show AKT1 Antibodies) induces albumin (show ALB Antibodies) endocytosis in proximal tubule epithelial cells.
Dab2 expression is induced by hormones
Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (show F2 Antibodies) in mice.
Study of dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Also, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism.
miR (show MLXIP Antibodies)-145 regulates the migration and invasion of highly invasive prostate cancer cells through targeting DAB2 gene
The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.
Data show that although small RNA-mediated Dab2 knockdown had no affect on the internalization of various clathrin-dependent cargo, TGF-beta (show TGFB1 Antibodies) receptor recycling was abrogated.
TGF-beta (show TGFB1 Antibodies) modulates the expression of Dab2 and ILEI (show FAM3C Antibodies) mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1 (show PCBP1 Antibodies), resulting in its release from a structural, 33-nucleotide BAT (show BAAT Antibodies) element in the 3'UTR (show UTS2R Antibodies) of Dab2 and ILEI (show FAM3C Antibodies).
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2, and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
, disabled homolog 2
, disabled homolog 2, mitogen-responsive phosphoprotein
, disabled homolog 2-like
, differentially-expressed protein 2
, mitogen-responsive phosphoprotein
, DOC-2 p82 isoform
, disabled homolog 2 mitogen-responsive phosphoprotein