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Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) Proteins (DAB2)

DAB2 encodes a mitogen-responsive phosphoprotein. Additionally we are shipping DAB2 Antibodies (84) and DAB2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DAB2 1601 P98082
DAB2 13132 P98078
DAB2 79128 O88797
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Top DAB2 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,247.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DAB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) Interaction Partners

Human Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) interaction partners

  1. Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 (show TGFB1 Proteins) which contributes to cell migration by targeting DAB2 in cervical carcinoma.

  2. these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages

  3. inhibition of WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart.

  4. DAB2 regulated the cell migration associated genes in PC3 (show PCSK1 Proteins) cells, and the differential DAB2 expression between LNCaP and PC3 (show PCSK1 Proteins) cells was partly regulated by histone 4 acetylation.

  5. Dab2 depletion also increases the rescued protein half-life of DeltaF508 CFTR (show CFTR Proteins) by ~18% and ~91%, respectively

  6. These results indicated that miR (show MLXIP Proteins)-93 plays an important role in the initiation and progression of NPC (show NPC1 Proteins) by targeting Dab2 and the miR (show MLXIP Proteins)-93/Dab2 pathway may contribute to the development of novel therapeutic strategies for NPC (show NPC1 Proteins) in the future.

  7. DAB2 expression is decreased in Non-Small Cell Lung Cancer , and the frequent methylation event at sites -86 to 226 of the DAB2 gene could contribute to the downregulation of DAB2.

  8. Attenuating Dab2 expression in K562 cells diminished TfR (show TFRC Proteins) internalization and increased surface levels of TfR (show TFRC Proteins) concomitantly with a decrease in Tf uptake and erythroid differentiation.

  9. Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis

  10. Numb (show NUMB Proteins) specifically regulates NPC1L1 (show NPC1L1 Proteins)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH (show LDLRAP1 Proteins) and Dab2, which selectively participate in LDLR (show LDLR Proteins)-mediated LDL uptake.

Mouse (Murine) Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) interaction partners

  1. Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.

  2. these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages

  3. Dab2 expression is induced by hormones

  4. Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis

  5. Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (show F2 Proteins) in mice.

  6. Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins) are involved in albumin (show ALB Proteins) endocytosis, and phosphorylation of Dab2 by Akt (show AKT1 Proteins) induces albumin (show ALB Proteins) endocytosis in proximal tubule epithelial cells.

  7. Study of dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Also, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism.

  8. miR (show MLXIP Proteins)-145 regulates the migration and invasion of highly invasive prostate cancer cells through targeting DAB2 gene

  9. The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.

  10. Data show that although small RNA-mediated Dab2 knockdown had no affect on the internalization of various clathrin-dependent cargo, TGF-beta (show TGFB1 Proteins) receptor recycling was abrogated.

Cow (Bovine) Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) interaction partners

  1. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2, and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

DAB2 Protein Profile

Protein Summary

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DAB2

  • disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2)
  • disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (dab2)
  • Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) (dab2)
  • Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) (DAB2)
  • Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) (Dab2)
  • disabled 2, mitogen-responsive phosphoprotein (Dab2)
  • 5730435J12Rik protein
  • AA960054 protein
  • AI957090 protein
  • D15Wsu122e protein
  • D630005B22Rik protein
  • Doc-2 protein
  • Doc2 protein
  • p96 protein

Protein level used designations for DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) , disabled homolog 2 , disabled homolog 2, mitogen-responsive phosphoprotein , disabled homolog 2-like , differentially-expressed protein 2 , mitogen-responsive phosphoprotein , C9 , DOC-2 p82 isoform , disabled homolog 2 mitogen-responsive phosphoprotein

GENE ID SPECIES
461905 Pan troglodytes
694349 Macaca mulatta
100019082 Monodelphis domestica
100066655 Equus caballus
100075899 Ornithorhynchus anatinus
100171587 Pongo abelii
100337568 Xenopus laevis
100411016 Callithrix jacchus
100484738 Ailuropoda melanoleuca
100485591 Xenopus (Silurana) tropicalis
100593149 Nomascus leucogenys
1601 Homo sapiens
100734816 Cavia porcellus
13132 Mus musculus
79128 Rattus norvegicus
427449 Gallus gallus
479353 Canis lupus familiaris
100519746 Sus scrofa
509221 Bos taurus
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