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Discs, Large Homolog 2 (Drosophila) Proteins (DLG2)

DLG2 encodes a member of the membrane-associated guanylate kinase (MAGUK) family. Additionally we are shipping DLG2 Antibodies (85) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DLG2 1740 Q15700
DLG2 23859 Q91XM9
Rat DLG2 DLG2 64053 Q63622
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Top DLG2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DLG2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Discs, Large Homolog 2 (Drosophila) (DLG2) Interaction Partners

Human Discs, Large Homolog 2 (Drosophila) (DLG2) interaction partners

  1. DLG2 - novel candidate genes validated in a large case-control sample of schizophrenia.

  2. The PDZ1 domain of PSD-93 might accept peptides with larger residues at the C-terminus than that of PSD-95 (show DLG4 Proteins), for example the GluD2 (show GLUD2 Proteins) C-terminal Ile versus the Val found at the C-terminus of NMDA receptors.

  3. This study showed that DLG2 is related the complex learning.

  4. Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 (show DLG4 Proteins) PDZ1 shows that they are very similar in terms of amino-acid composition

  5. Variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin (show INS Proteins) sensitivity and beta-cell function.

  6. Coexpression of Kir2.1 (show KCNJ2 Proteins) and PSD (show PSD Proteins)-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 (show KCNJ2 Proteins) clustering and suppression of channel internalization.

  7. identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma

Mouse (Murine) Discs, Large Homolog 2 (Drosophila) (DLG2) interaction partners

  1. Downregulation of nAChR (show CHRNA4 Proteins) subunit and PSD-93 expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG (show MPG Proteins) and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries.

  2. Membrane-associated guanylate kinase (show GUK1 Proteins) homolog PSD-93 is a central organizer of the postsynaptic density at excitatory synapses on pyramidal neurons.

  3. These data show critical roles for psd-93 and interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes.

  4. Since NMDARs, Ca(2 (show CA2 Proteins)+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders.

  5. PSD-93 deficiency in knock-out mice results in a decrease in the minimum alveolar anesthetic concentration of halothane.

  6. PSD-93 serves as a membrane-anchored substrate of Fyn (show FYN Proteins) and plays a role in the regulation of Fyn (show FYN Proteins)-mediated modification of NMDA receptor function

  7. PSD93 containing complexes regulates synaptic stability at neuronal cholinergic synapses.

  8. PSD-93 appears to mediate tyrosine-phosphorylation of the NMDA receptors

  9. PSD-93 deficiency significantly decreased the amount of NR2A (show GRIN2A Proteins) and NR2B (show GRIN2B Proteins) in the synaptosomal membrane fractions

  10. PSD-95 (show DLG4 Proteins) and PSD-93 have distinct roles in synaptic plasticity, perhaps through differential recruitment of signalling molecules to the NMDA receptor.

DLG2 Protein Profile

Protein Summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known.

Gene names and symbols associated with DLG2

  • discs, large (Drosophila) homolog 2 (dlg2)
  • discs, large homolog 2 (Drosophila) (DLG2)
  • discs, large homolog 2 (Drosophila) (Dlg2)
  • A330103J02Rik protein
  • B230218P12Rik protein
  • B330007M19Rik protein
  • chapsyn-110 protein
  • Dlgh2 protein
  • Gm1197 protein
  • PPP1R58 protein
  • PSD-93 protein
  • PSD93 protein

Protein level used designations for DLG2

PSD-93 , disks large homolog 2 , postsynaptic density protein 93 , channel-associated protein of synapse-110 , channel-associated protein of synapses, 110kDa , discs, large homolog 2, chapsyn-110 , postsynaptic density protein PSD-93 , protein phosphatase 1, regulatory subunit 58 , chapsyn-110 , discs large homolog 2 , synaptic density protein PSD-93

GENE ID SPECIES
497638 Danio rerio
1740 Homo sapiens
23859 Mus musculus
64053 Rattus norvegicus
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