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Discs, Large Homolog 3 (Drosophila) Proteins (DLG3)

DLG3 encodes a member of the membrane-associated guanylate kinase protein family. Additionally we are shipping DLG3 Antibodies (82) and DLG3 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DLG3 58948 Q62936
DLG3 1741 Q92796
DLG3 53310 P70175
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Top DLG3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Rat GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DLG3 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,
Mouse (Murine)

More Proteins for Discs, Large Homolog 3 (Drosophila) (DLG3) Interaction Partners

Human Discs, Large Homolog 3 (Drosophila) (DLG3) interaction partners

  1. Insertion of a guanine into the DLG3 5' UTR, 7 bp upstream of the start codon, down regulated DLG3 protein levels. This non-coding variant segregates with X-linked intellectual disability in a large family.

  2. Trans-homophilic interaction of CADM1 (show CADM1 Proteins) activates PI3K (show PIK3CA Proteins) by forming a complex with MAGuK-family proteins MPP3 (show MPP3 Proteins) and Dlg (show DLG4 Proteins).

  3. miR (show MLXIP Proteins)-1246 might play a role in neurological pathogenesis of human enterovirus 71 by regulating DLG3 gene in infected cells.

  4. These data shed new light on the role of SAP102 in the regulation of NMDAR (show GRIN1 Proteins) trafficking.

  5. This study identified DLG3 significantly associated loci with a biologically plausible role in schizophrenia.

  6. The data of this study suggested that DLG3 is down-regulated in this cancer type.

  7. The PDZ-independent interaction between SAP102 and GluN2B (show GRIN2B Proteins) mediates the synaptic clearance of GluN2B (show GRIN2B Proteins)-containing NMDARs.(SAP102 protein)

  8. Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.

  9. DLG3 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin. DLG3 was also found to correlate with cellular sensitivity to platinating agents in NCI-60 cancer cell lines.

  10. DLG3 did not associate with non-syndromic mental retardation in Chinese Han population; however, further studies are needed.

Mouse (Murine) Discs, Large Homolog 3 (Drosophila) (DLG3) interaction partners

  1. our current study identified a functional interplay between PSD-95 (show DLG4 Proteins) and synapse-associated protein 102 (SAP102) to regulate synaptic AMPA (show GRIA3 Proteins) receptors

  2. SAP102 has a fundamental role in trafficking the NMDA receptor complex to the synaptic sites.

  3. The Dlg3 have functions in complex cognitive processes.

  4. Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.

  5. Dlg3 exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 (show NEDD4L Proteins) through its PPxY motifs. These interactions are required for Dlg3 monoubiquitination, apical membrane recruitment, and tight junction consolidation.

  6. Membrane-associated guanylate kinase (show GUK1 Proteins) homolog SAP102 is a central organizers of the postsynaptic density at excitatory synapses on pyramidal neurons.

  7. SAP102 interacts with the PDZ-binding domain of Sec8 (show EXOC4 Proteins), a member of the exocyst complex. nteractions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons.

  8. SAP102 was required for normal spatial learning. Loss of SAP102 results in changes in spatial strategy usage. Altered long term potentiation and spike-timing-dependent plasticity in SAP102 mutants. Couples NMDA receptors to MAPK/ERK (show MAPK1 Proteins) pathway.

  9. Results describe E-dlg (show DLG4 Proteins), a mouse homologue of the Drosophila discs large (show DLG4 Proteins) tumor suppressor (Dlg (show DLG4 Proteins), also known as SAP97 (show DLG1 Proteins)), that binds preferentially to SAP102.

  10. SAP102 and PSD-95 (show DLG4 Proteins) regulate the synaptic trafficking of distinct glutamate (show GRIN1 Proteins) receptor subtypes at different developmental stages, thereby playing necessary roles in excitatory synapse development.

DLG3 Protein Profile

Protein Summary

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with DLG3

  • discs, large homolog 3 (DLG3)
  • discs, large homolog 3 (Drosophila) (Dlg3)
  • discs, large homolog 3 (Drosophila) (DLG3)
  • discs, large homolog 3 (Drosophila) (dlg3)
  • Dlgh3 protein
  • fa66c08 protein
  • fa66e02 protein
  • fd02c12 protein
  • fu95c12 protein
  • im:7138640 protein
  • mKIAA1232 protein
  • MPP3 protein
  • MRX protein
  • MRX90 protein
  • NEDLG protein
  • SAP102 protein
  • si:ch211-276g21.1 protein
  • wu:fa66c08 protein
  • wu:fa66e02 protein
  • wu:fd02c12 protein
  • wu:fu95c12 protein
  • XLMR protein

Protein level used designations for DLG3

PSD-95/SAP90-related protein 1 , SAP-102 , SAP102 , discs large homolog 3 , disks large homolog 3 , synapse-associated protein 102 , neuroendocrine-DLG , discs, large homolog 3 (neuroendocrine-dlg, Drosophila) , membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

GENE ID SPECIES
100516124 Sus scrofa
58948 Rattus norvegicus
1741 Homo sapiens
53310 Mus musculus
564081 Danio rerio
428706 Gallus gallus
491942 Canis lupus familiaris
509882 Bos taurus
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