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DnaJ (Hsp40) Homolog, Subfamily C, Member 3 Proteins (DNAJC3)

DNAJC3 encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. Additionally we are shipping DnaJ (Hsp40) Homolog, Subfamily C, Member 3 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNAJC3 5611 Q13217
DNAJC3 100037258 Q91YW3
DNAJC3 63880 Q9R0T3
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Top DnaJ (Hsp40) Homolog, Subfamily C, Member 3 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,331.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,334.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,334.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DNAJC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) Interaction Partners

Human DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) interaction partners

  1. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

  2. Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans.

  3. p58 (show CDK11B Proteins)(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway that requires activation of ATF6a (show ATF6 Proteins) and subsequently upregulates mitofusin 2 (show MFN2 Proteins).

  4. interplay between p38 (show CRK Proteins) phosphorylation and p58 (show CDK11B Proteins)(IPK) upregulation has key roles in modulating ERp29 (show ERP29 Proteins)-induced cell-growth arrest and survival

  5. the crystal structure of human P58 (show CDK11B Proteins)(IPK)

  6. Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP (show DDIT3 Proteins) and SREBP1 (show SREBF1 Proteins).

  7. Spleen cells from transgenic mice overexpressing (Hu)PKR were studied and compared to those from wild-type mice after drug treatment. Dact-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division.

  8. P58 (show CDK11B Proteins)(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha (show EIF2A Proteins) signaling, and thus attenuate the unfolded protein response.

  9. The study demonstrates that P58 (show CDK11B Proteins)(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells.

Pig (Porcine) DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) interaction partners

  1. Cloning, prokaryotic expression of novel swine gene P58IPK and its polyclonal antibody preparation

Mouse (Murine) DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) interaction partners

  1. Chaperone protein p58 (show CDK11B Proteins)(IPK) is expressed predominantly in retinal ganglion cells (RGC), inner retinal neurons, and the photoreceptor inner segments.

  2. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

  3. combined deletion of ATF6alpha (show ATF6 Proteins) and the ER cochaperone p58 (show CDK11B Proteins)(IPK) resulted in synthetic embryonic lethality.

  4. Data present a working model for P58 (show CDK11B Proteins)(IPK) to act together with Bip (show HSPA5 Proteins) to prevent protein aggregations and promote protein foldings within ER.

  5. Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP (show DDIT3 Proteins) and SREBP1 (show SREBF1 Proteins).

  6. mechanism by which P58 (show CDK11B Proteins)(IPK) functions to promote protein folding within the endoplasmic reticulum, determined from the crystal structure of P58 (show CDK11B Proteins)(IPK)

  7. renal injury inflicted by expression of the folding mutants was markedly enhanced by haploinsufficiency of the endoplasmic reticulum cochaperone p58 (show CDK11B Proteins)(IPK).

  8. The stress of unfolded proteins in the ER activates P58(IPK) transcription through an ER stress-response element in its promoter. P58(IPK) interacts with & inhibits PERK, which protects cells during the ER-stress response by reducing protein synthesis.

  9. Insulin (show INS Proteins) deficiency associated with the absence of P58 (show CDK11B Proteins)(IPK) mimics beta-cell failure associated with type 1 and late-stage type 2 diabetes.

  10. absence of P58 (show CDK11B Proteins)(IPK) led to an increase in eIF2alpha (show EIF2A Proteins) phosphorylation and decreased influenza virus mRNA translation

DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) Protein Profile

Protein Summary

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).

Gene names and symbols associated with DNAJC3

  • DnaJ (Hsp40) homolog, subfamily C, member 3 (dnajc3)
  • DnaJ (Hsp40) homolog, subfamily C, member 3 (DNAJC3)
  • DNAJ heat shock N-terminal domain-containing protein (dnajc3)
  • DnaJ (Hsp40) homolog, subfamily C, member 3 (Dnajc3)
  • AA408985 protein
  • AU067833 protein
  • cg8286 protein
  • DDBDRAFT_0186884 protein
  • DDBDRAFT_0233602 protein
  • DDB_0186884 protein
  • DDB_0233602 protein
  • dnajc3 protein
  • Dnajc3a protein
  • Dnajc3b protein
  • ERdj6 protein
  • HP58 protein
  • mp58 protein
  • p58 protein
  • p58IPK protein
  • Prkri protein
  • wu:fb64f06 protein
  • zgc:56356 protein
  • zgc:77731 protein

Protein level used designations for DNAJC3

dnaJ homolog subfamily C member 3 , DnaJ (Hsp40) homolog, subfamily C, member 3 , Interferon-induced, double-stranded RNA-activated protein kinase inhibitor , TPR repeat-containing protein , endoplasmic reticulum DnaJ protein 6 , interferon-induced, double-stranded RNA-activated protein kinase inhibitor , protein kinase inhibitor of 58 kDa , protein kinase inhibitor p58 , protein-kinase, interferon-inducible double stranded RNA dependent inhibitor , DnaJ (Hsp40) homolog, subfamily C, member 3A , DnaJ (Hsp40) homolog, subfamily C, member 3B , protein kinase, interferon inducible double stranded RNA dependent inhibitor

GENE ID SPECIES
322544 Danio rerio
476966 Canis lupus familiaris
496977 Xenopus (Silurana) tropicalis
695757 Macaca mulatta
736800 Pan troglodytes
8625524 Dictyostelium discoideum AX4
100019766 Monodelphis domestica
100059810 Equus caballus
100393937 Callithrix jacchus
100446513 Pongo abelii
100467911 Ailuropoda melanoleuca
100597711 Nomascus leucogenys
379791 Xenopus laevis
5611 Homo sapiens
286770 Bos taurus
100154166 Sus scrofa
100037258 Mus musculus
63880 Rattus norvegicus
418787 Gallus gallus
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