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DNAJB2 is almost exclusively expressed in the brain, mainly in the neuronal layers. Additionally we are shipping DnaJ (Hsp40) Homolog, Subfamily B, Member 2 Proteins (9) and many more products for this protein.
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Study describes the identi fi cation of the fi rst (show SLC22A12 Antibodies) deletion reported at the DNAJB2 locus, further expanding its phenotypic and genotypic spectrums as well as its disease-associated mechanisms with spinal muscular atrophy and parkinsonism.
Our results disclose a novel interplay between ubiquitin- and phosphorylation-dependent signalling, and represent the first report of a regulatory mechanism for UIM-dependent function. They also suggest that CK2 (show CSNK2A1 Antibodies) inhibitors could release the full neuroprotective potential of HSJ1, and deserve future interest as therapeutic strategies for neurodegenerative disease.
The results of this study confirm that HSJ1 mutations are a rare but detectable cause of autosomal recessive dHMN and CMT2.
HSJ1a acts on mutant SOD1 (show SOD1 Antibodies) through a combination of chaperone, co-chaperone and pro-ubiquitylation activity.
a mutation causing a loss-of-function of HSJ1 is linked to a pure lower motor neuron disease, strongly suggesting that HSJ1 also plays an important and specific role in motor neurons.
Data show that DNAJB2 is expressed in skeletal muscle at the neuromuscular junction of normal fibers, in the cytoplasm and membrane of regenerating fibers, and in protein aggregates and vacuoles in protein aggregate myopathies.
data provide evidence that cytoplasmic chaperones HSJ1a and HSJ1b when targeted to the endoplasmic reticulum can influence the folding and processing of rhodopsin (show RHO Antibodies)
HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
Damaging exercise induced the expression of capZalpha, MCIP1 (show RCAN1 Antibodies), CARP1 (show CCAR1 Antibodies), DNAJB2, c-myc (show MYC Antibodies), and junD (show JUND Antibodies), each of which are likely involved in skeletal muscle growth, remodeling, and stress management.
Hsc70 (show HSPA8 Antibodies), Hdj1 (show DNAJB1 Antibodies) and Hdj2 (show DNAJA1 Antibodies) interact with soluble and fibrillar alpha-synuclein (show SNCA Antibodies)
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
DnaJ (Hsp40) homolog, subfamily B, member 2
, dnaJ homolog subfamily B member 2
, novel DnaJ (Hsp40) homolog, subfamily B (dnajb) member
, dnaJ protein homolog 1
, heat shock 40 kDa protein 3
, heat shock protein J1
, heat shock protein, neuronal DNAJ-like 1
, DnaJ (Hsp40) homolog, subfamily B, member 10
, dnaJ homolog subfamily B member 10
, heat shock protein, DNAJ-like 1