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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Kits (15) and DUSP1 Proteins (5) and many more products for this protein.
Showing 10 out of 105 products:
Human Polyclonal DUSP1 Primary Antibody for EIA, WB - ABIN360822
Wu, Pew, Zou, Pang, Conzen: Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. in The Journal of biological chemistry 2005
Show all 5 references for ABIN360822
Human Polyclonal DUSP1 Primary Antibody for IHC, ELISA - ABIN184638
Alessi, Smythe, Keyse: The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. in Oncogene 1993
Human Polyclonal DUSP1 Primary Antibody for IF (p) - ABIN894519
Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014
Human Polyclonal DUSP1 Primary Antibody for IHC, ELISA - ABIN1532716
Keyse, Emslie: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. in Nature 1992
The heparin effects on TNFalpha (show TNF Antibodies)-induced stress fiber formation and Map kinase (show MAPK1 Antibodies) signaling depend on increased DUSP1 expression.
evidence of association between depressive symptom severity and increasing serum MKP-1 levels in women, and decreasing T levels in perimenopausal women.
MKP-1 can attenuate tamoxifen-induced cell death through inhibiting the JNK (show MAPK8 Antibodies) signal pathway.
Progesterone acts via GR to drive MKP-1 expression, which in turn inhibits IL-1beta (show IL1B Antibodies)-dependent c-Jun (show JUN Antibodies) activation and COX-2 (show COX2 Antibodies) expression.
Data show that sorafenib inhibited microRNA miR (show MLXIP Antibodies)-101 expression and enhanced dual specificity phosphatase 1 (DUSP1) expression and lowered transforming growth factor beta I (TGF-beta (show TGFB1 Antibodies)) release in M2 macrophage, slowing macrophage-driven hepatocarcinoma.
DUSP1 overexpression and inhibition of MAPKs prevented IL1B (show IL1B Antibodies)-induced expression of ZFP36 (show ZFP36 Antibodies), this was associated with increased TNF (show TNF Antibodies) mRNA expression at 6 h, an effect that was predominantly due to elevated transcription.
MKP-1 is a MAPK (show MAPK1 Antibodies) deactivator; thus, by controlling p38 MAPK (show MAPK14 Antibodies) phosphorylation status in a temporally distinct manner, MKP-1 ensures that TTP (show ADAMTS13 Antibodies) is expressed and made functional at precisely the correct time to repress cytokine expression.
Wild-type but not mutant p53 (show TP53 Antibodies) transcriptionally upregulated DUSP1 via its DNA-binding domain. DUSP1 and p53 (show TP53 Antibodies) might collaborate to suppress tumors in hepatocarcinogenesis via a positive regulatory loop.
Data (including data from studies in knockout mice) suggest AMPK (show PRKAA1 Antibodies) activation (AMPKa1 (show PRKAA1 Antibodies) or AMPKa2 (show PRKAA2 Antibodies)) suppresses inflammation in vascular smooth muscle cells by down-regulation of STAT1 (show STAT1 Antibodies) signaling and up-regulation of MKP-1 (dual specificity phosphatase 1).
DUSP1 is involved in the antiviral host defense mechanism against a HCV infection
A2AR (show ADORA2A Antibodies) signaling regulates both basal and LPS (show TLR4 Antibodies)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.
these data suggest an important role for DUSPs in regulating MAPK (show MAPK1 Antibodies) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis
Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.
Nr4a1 (show NR4A1 Antibodies) induction is dependent on ERK1/2 (show MAPK1/3 Antibodies) and that MKP-1 negatively regulates this induction.
MKP-1 negatively regulates chemokine (show CCL1 Antibodies)-driven osteoclast formation and subsequent bone resorption in response to LPS (show TLR4 Antibodies) stimulation
results suggest that the p38alpha (show MAPK14 Antibodies)-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.
DUSP1 and tristetraprolin (show ZFP36 Antibodies) cooperate to regulate macrophage responses to lipopolysaccharide.
MKP-1 regulated the expression of MMP-12 (show MMP12 Antibodies).
CYLD (show CYLD Antibodies) negatively regulates nontypeable Haemophilus influenzae-induced IL-8 (show IL8 Antibodies) expression via MKP-1-dependent inhibition of ERK (show EPHB2 Antibodies).
Ozone exposure decreased the protein expression of MKP-1 in an asthma model.
MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2 (show MAPK1/3 Antibodies)-mediated aldosterone production in response to the hormone.
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
dual specificity protein phosphatase 1
, dual specificity phosphatase 1
, MAP kinase phosphatase 1
, dual specificity protein phosphatase hVH1
, mitogen-activated protein kinase phosphatase 1
, protein-tyrosine phosphatase CL100
, serine/threonine specific protein phosphatase
, mitogen-activated protein kinase phosphatase-1
, protein tyrosine phosphatase, non-receptor type 16
, protein-tyrosine phosphatase 3CH134
, protein-tyrosine phosphatase ERP
, 3CH134/CL100 PTPase
, MAP kinase phosphatase-1
, mitogen-activated protein (MAP) kinase phosphatase-1
, oxidative stress-inducible protein tyrosine phosphatase
, protein tyrosine phosphatase non-receptor type 16
, protein-tyrosine phosphatase non-receptor type 16
, MAPK phosphatase 1