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anti-Dual Specificity Phosphatase 1 (DUSP1) Antibodies

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Kits (15) and DUSP1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DUSP1 1843 P28562
DUSP1 19252 P28563
DUSP1 114856 Q64623
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Top anti-DUSP1 Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184638 (3.8µg/ml) staining of paraffin embedded Human Prostate. St... ABIN184638 (0.3µg/ml) staining of HeLa lysate (35µg protein in RIPA bu... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Cow Goat Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinom... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using MKP1 (Ab-35... Immunohistochemistry analysis of paraffin-embedded human brain tissue,... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Goat Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF, WB The anti-DUSP1 Pab (ABIN392905) is used in Western blot to detect DUSP... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Placenta (formalin-fixed, paraffin-embedded) stained with DUSP1 ... 50 μg Log in to see 8 to 10 Days
$595.83
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Prostate (formalin-fixed, paraffin-embedded) stained with DUSP1 ... 50 μg Log in to see 8 to 10 Days
$451.00
Details

DUSP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-DUSP1 Antibodies

  1. Human Polyclonal DUSP1 Primary Antibody for EIA, WB - ABIN360822 : Wu, Pew, Zou, Pang, Conzen: Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for ABIN360822

  2. Human Polyclonal DUSP1 Primary Antibody for IHC, ELISA - ABIN184638 : Alessi, Smythe, Keyse: The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. in Oncogene 1993 (PubMed)

  3. Human Polyclonal DUSP1 Primary Antibody for IF (p) - ABIN894519 : Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014 (PubMed)

  4. Human Polyclonal DUSP1 Primary Antibody for IHC, ELISA - ABIN1532716 : Keyse, Emslie: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. in Nature 1992 (PubMed)

More Antibodies against DUSP1 Interaction Partners

Human Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. The heparin effects on TNFalpha (show TNF Antibodies)-induced stress fiber formation and Map kinase (show MAPK1 Antibodies) signaling depend on increased DUSP1 expression.

  2. evidence of association between depressive symptom severity and increasing serum MKP-1 levels in women, and decreasing T levels in perimenopausal women.

  3. MKP-1 can attenuate tamoxifen-induced cell death through inhibiting the JNK (show MAPK8 Antibodies) signal pathway.

  4. Progesterone acts via GR to drive MKP-1 expression, which in turn inhibits IL-1beta (show IL1B Antibodies)-dependent c-Jun (show JUN Antibodies) activation and COX-2 (show COX2 Antibodies) expression.

  5. Data show that sorafenib inhibited microRNA miR (show MLXIP Antibodies)-101 expression and enhanced dual specificity phosphatase 1 (DUSP1) expression and lowered transforming growth factor beta I (TGF-beta (show TGFB1 Antibodies)) release in M2 macrophage, slowing macrophage-driven hepatocarcinoma.

  6. DUSP1 overexpression and inhibition of MAPKs prevented IL1B (show IL1B Antibodies)-induced expression of ZFP36 (show ZFP36 Antibodies), this was associated with increased TNF (show TNF Antibodies) mRNA expression at 6 h, an effect that was predominantly due to elevated transcription.

  7. MKP-1 is a MAPK (show MAPK1 Antibodies) deactivator; thus, by controlling p38 MAPK (show MAPK14 Antibodies) phosphorylation status in a temporally distinct manner, MKP-1 ensures that TTP (show ADAMTS13 Antibodies) is expressed and made functional at precisely the correct time to repress cytokine expression.

  8. Wild-type but not mutant p53 (show TP53 Antibodies) transcriptionally upregulated DUSP1 via its DNA-binding domain. DUSP1 and p53 (show TP53 Antibodies) might collaborate to suppress tumors in hepatocarcinogenesis via a positive regulatory loop.

  9. Data (including data from studies in knockout mice) suggest AMPK (show PRKAA1 Antibodies) activation (AMPKa1 (show PRKAA1 Antibodies) or AMPKa2 (show PRKAA2 Antibodies)) suppresses inflammation in vascular smooth muscle cells by down-regulation of STAT1 (show STAT1 Antibodies) signaling and up-regulation of MKP-1 (dual specificity phosphatase 1).

  10. DUSP1 is involved in the antiviral host defense mechanism against a HCV infection

Mouse (Murine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. these data suggest an important role for DUSPs in regulating MAPK (show MAPK1 Antibodies) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis

  2. Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.

  3. Nr4a1 (show NR4A1 Antibodies) induction is dependent on ERK1/2 (show MAPK1/3 Antibodies) and that MKP-1 negatively regulates this induction.

  4. MKP-1 negatively regulates chemokine (show CCL1 Antibodies)-driven osteoclast formation and subsequent bone resorption in response to LPS (show TLR4 Antibodies) stimulation

  5. results suggest that the p38alpha (show MAPK14 Antibodies)-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.

  6. DUSP1 and tristetraprolin (show ZFP36 Antibodies) cooperate to regulate macrophage responses to lipopolysaccharide.

  7. MKP-1 regulated the expression of MMP-12 (show MMP12 Antibodies).

  8. CYLD (show CYLD Antibodies) negatively regulates nontypeable Haemophilus influenzae-induced IL-8 (show IL8 Antibodies) expression via MKP-1-dependent inhibition of ERK (show EPHB2 Antibodies).

  9. Ozone exposure decreased the protein expression of MKP-1 in an asthma model.

  10. hepatic MKP-1 serves as a selective regulator of MAPK (show MAPK1 Antibodies)-dependent signals that contributes to the maintenance of glucose homeostasis and peripheral tissue energy balance

Cow (Bovine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2 (show MAPK1/3 Antibodies)-mediated aldosterone production in response to the hormone.

DUSP1 Antigen Profile

Protein Summary

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Gene names and symbols associated with DUSP1

  • dual specificity phosphatase 1 (DUSP1) antibody
  • dual specificity phosphatase 1 (dusp1) antibody
  • dual specificity phosphatase 1 (Dusp1) antibody
  • 3CH134 antibody
  • cb269 antibody
  • CL100 antibody
  • DUSP1 antibody
  • erp antibody
  • HVH1 antibody
  • id:ibd2586 antibody
  • mkp-1 antibody
  • Mkp1 antibody
  • PTPN10 antibody
  • Ptpn16 antibody
  • sb:cb269 antibody
  • U19515 antibody
  • wu:fd19g02 antibody
  • wu:fe50g09 antibody
  • zgc:55920 antibody

Protein level used designations for DUSP1

dual specificity protein phosphatase 1 , dual specificity phosphatase 1 , mkp-1 , MAP kinase phosphatase 1 , dual specificity protein phosphatase hVH1 , mitogen-activated protein kinase phosphatase 1 , protein-tyrosine phosphatase CL100 , serine/threonine specific protein phosphatase , mitogen-activated protein kinase phosphatase-1 , protein tyrosine phosphatase, non-receptor type 16 , protein-tyrosine phosphatase 3CH134 , protein-tyrosine phosphatase ERP , 3CH134/CL100 PTPase , MAP kinase phosphatase-1 , mitogen-activated protein (MAP) kinase phosphatase-1 , oxidative stress-inducible protein tyrosine phosphatase , protein tyrosine phosphatase non-receptor type 16 , protein-tyrosine phosphatase non-receptor type 16 , MAPK phosphatase 1

GENE ID SPECIES
374192 Gallus gallus
471742 Pan troglodytes
100219518 Taeniopygia guttata
100340993 Oryctolagus cuniculus
406340 Danio rerio
1843 Homo sapiens
19252 Mus musculus
114856 Rattus norvegicus
489117 Canis lupus familiaris
539175 Bos taurus
100522469 Sus scrofa
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