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Dynamins represent one of the subfamilies of GTP-binding proteins. Additionally we are shipping Dynamin 2 Antibodies (42) and Dynamin 2 Kits (36) and many more products for this protein.
Showing 5 out of 7 products:
uncover a link between the dynamin 2 function and JNK (show MAPK8 Proteins) signaling which leads to AP-1 (show FOSB Proteins) induction
results provide evidence for a novel Arf6 (show ARF6 Proteins) activation mechanism by Dyn2 through EFA6B and EFA6D (show PSD3 Proteins) in CME in a manner dependent upon the GTPase (show RACGAP1 Proteins) activity of Dyn2
We conclude that DNM2 is a novel negative regulator of NO production in mouse collecting ducts.
In marked contrast to invadopodia, this degradation does not require the action of Src kinase (show CSK Proteins), Cdc42 (show CDC42 Proteins) or Dyn2. Rather, inhibition of Dyn2 causes a marked upregulation of stromal matrix degradation
exome sequencing family study reveals that autosomal dominant spastic paraplegia linked to a GTPase (show RACGAP1 Proteins)-effector domain mutation of dynamin 2
This study demonistrated that DNM2 mutation releated to Centronuclear myopathy.
Dynamin 2 deletion in beta cells caused glucose intolerance and reduced the 2d phase of glucose-stimulated insulin secretion. Dynamin 2 regulates insulin secretory capacity and dynamics in vivo via a mechanism depending on CME and F-actin remodeling.
this study described for the first time the clinical, pathological and genetic features of DNM2-related CNM (show MTM1 Proteins) in Chinese patients.
Dynamin 1 (show DNM1 Proteins) and dynamin 2 activity are not essential for Chlamydia trachomatis internalization but is required for normal development.
Data indicate that dynamin 2 (Dyn2) interacts with Connexin 26 (Cx26 (show GJB2 Proteins)) in a yeast two-hybrid screen, and co-localizes in mammalian cells.
Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.
Dynamin 2 might participate in the early embryonic development through an actin-based cytokinesis
Dynamin 2 has a role in endocytosis and in sustaining T-cell receptor signaling and driving metabolic reprogramming in T lymphocytes
DNM2-dependent endocytosis in megakaryocytes regulates megakaryopoiesis, thrombopoiesis, and bone marrow homeostasis.
Thus dynamin (show DNM1 Proteins) that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell-cell fusion processes.
Using an inducible knockout mouse model to generate dynamin 1 (show DNM1 Proteins)- and 2-deficient primary osteoclast precursors and myoblasts, it was shown that fusion of both cell types requires dynamin (show DNM1 Proteins).
FGF21 (show FGF21 Proteins) has a role in promoting endothelial cell angiogenesis through a dynamin-2 and Rab5 (show RAB5A Proteins) dependent pathway
Dynamin 2 regulates spindle migration and polar body extrusion during mouse oocyte meiosis through an actin-based pathway
As low-level expression of the dynamin 3 (show DNM3 Proteins) gene in these cells could not be excluded, we have now engineered dynamin 1 (show DNM1 Proteins), 2 and 3 triple KO (TKO (show MRPS12 Proteins)) fibroblasts.
Dynamin 2 deficiency caused impaired egress through regulation of S1PR1 (show S1PR1 Proteins) signaling.
Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release.
role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase (show NOS3 Proteins) activity.
Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity.
LKT-mediated cell death involve dynamin-2 and cyclophilin D (show PPIF Proteins)
DNM2-S619L causes disease, in part, by interfering with membrane tubulation
Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.
Dynamin 2 possibly regulates porcine oocyte maturation through its effects on actin-mediated spindle positioning and cytokinesis, and that this may depend on regulating ARP2 (show ACTR2 Proteins) localization.
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
, dynamin 2
, dynamin II