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DTNBP1 encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Additionally we are shipping Dystrobrevin Binding Protein 1 Proteins (16) and Dystrobrevin Binding Protein 1 Kits (6) and many more products for this protein.
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Human Polyclonal DTNBP1 Primary Antibody for EIA, WB - ABIN952010
Haukvik, Saetre, McNeil, Bjerkan, Andreassen, Werge, Jönsson, Agartz: An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. in Progress in neuro-psychopharmacology & biological psychiatry 2010
Show all 3 references for ABIN952010
Human Polyclonal DTNBP1 Primary Antibody for EIA, IHC (p) - ABIN357846
Benson, Newey, Martin-Rendon, Hawkes, Blake: Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. in The Journal of biological chemistry 2001
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Human Polyclonal DTNBP1 Primary Antibody for EIA, IHC (p) - ABIN357845
Li, Zhang, Oiso, Novak, Gautam, OBrien, Tinsley, Blake, Spritz, Copeland, Jenkins, Amato, Roe, Starcevic, DellAngelica, Elliott, Mishra, Kingsmore, Paylor, Swank: Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). in Nature genetics 2003
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Results indicate that perturbations downstream of DTNBP1, confer susceptibility to copper, a metal that in excess (show RCC1 Antibodies) is a neurotoxin and whose depletion constitutes a micronutrient deficiency.
Loss-of-function alleles of dysbindin or Blos1 (show BLOC1S1 Antibodies) impaired neurotransmitter release and synaptic function and plasticity.
optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects. Thus, Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal
study found that dysbindin (CG6856) is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx
Authors report the examination of DNA methylation status of DTNBP1 promoter region, one of the most credible candidate genes affected in SCZ.
DTNBP1 is likely to play a role in development of auditory related, visual and olfactory hallucinations
dysbindin-1A protein levels are highly regulated in the nucleus and that dysbindin-1A regulates transcription factor NF-kappa B (show NFKB1 Antibodies) activity to promote the expression of MMP-9 (show MMP9 Antibodies) and TNF-alpha (show TNF Antibodies)
Study demonstrated that dysbindin-1B, rather than dysbindin-1A and dysbindin-1C, has the ability to aggregate
The present findings intransgenic mice expressing human DTNBP1 support the role of dysbindin-1 in psychiatric disorders.
Findings add further evidence suggesting an association between dysbindin gene variability and cognitive abnormalities in schizophrenia.
dysbindin-1 formed a protein complex with HDAC3 (show HDAC3 Antibodies) in human neuroblastoma (show ARHGEF16 Antibodies) cells
DISC1 forms a complex with dysbindin and increases its sta (show DISC1 Antibodies)bility in association with a reduction in ubiquitylation.
In homozygotes and heterozygotes of risk allele (CC) of DTNBP1, there was a trend to volumetric reductions in brain regions, regardless of schizophrenia diagnosis.
loss of function mutations in the genes encoding dysbindin and its interacting BLOC-1 (show BLOC1S1 Antibodies) subunits
Dysbindin-1 modulates thus D2 and D3 receptor (show DRD3 Antibodies) signaling, supporting a link to schizophrenia
Results suggest that Dtnbp1 deficiency may lead to increased vulnerability to schizophrenia under environmental conditions where circadian rhythms are altered
Snapin-dysbindin interaction regulates synaptic vesicle positional priming through BLOC-1/AP-3-dependent sorting.
Dysbindin has three isoforms associating with different complexes in the P2 fraction of mouse brain.
Dysbindin-1C deficiency causes impaired autophagy, which is likely implicated in the pathogenesis of schizophrenia.
The neurite outgrowth defect induced by knockdown of DISC1 (show DISC1 Antibodies) was partially reversed by coexpression of dysbindin.
dysbindin-1C, rather than dysbindin-1A, regulates adult hippocampal neurogenesis in a non-cell autonomous manner
loss of function mutations in the genes encoding dysbindin and its interacting BLOC-1 (show PLDN Antibodies) subunits
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT (show COMT Antibodies) and DTNBP1.
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
, BLOC-1 subunit 8-A
, biogenesis of lysosome-related organelles complex 1 subunit 8-A
, dystrobrevin binding protein 1
, dystrobrevin-binding protein 1-A
, BLOC-1 subunit 8
, Hermansky-Pudlak syndrome 7 protein
, biogenesis of lysosomal organelles complex-1, subunit 8
, biogenesis of lysosome-related organelles complex 1 subunit 8
, HPS7 protein homolog
, dystrobrevin-binding protein 1
, hermansky-Pudlak syndrome 7 protein homolog
, distrobrevin binding protein 1