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ERLIN2 encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. Additionally we are shipping ERLIN2 Proteins (11) and ERLIN2 Kits (9) and many more products for this protein.
Showing 10 out of 51 products:
Fruit Fly (Drosophila melanogaster) Polyclonal ERLIN2 Primary Antibody for WB - ABIN2787692
Pearce, Wang, Kelley, Wojcikiewicz: SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells. in The Journal of biological chemistry 2007
Show all 2 references for ABIN2787692
Human Polyclonal ERLIN2 Primary Antibody for WB - ABIN374598
Garcia, Pole, Chin, Teschendorff, Naderi, Ozdag, Vias, Kranjac, Subkhankulova, Paish, Ellis, Brenton, Edwards, Caldas: A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. in Oncogene 2005
Show all 2 references for ABIN374598
swine erlin2 gene has a closer genetic relationship with the erlin2 genes of human and rhesus monkey. This gene is differentially expressed in the liver tissues from Meishan and Large White pigs.
Here we show that the multimeric ER proteins erlins-1 and -2 are additional sterol regulatory element binding protein (show CNBP Antibodies) regulators.
ERLIN2 was found to be responsible for causing hereditary spastic paraplegia in a Saudi family.
ERLIN2 may confer a selective growth advantage for breast cancer cells by facilitating a cytoprotective response to various cellular stresses associated with oncogenesis.
ERLIN2 loss on cell growth may advance understanding of the mechanism behind motor neuron degeneration (show CLN8 Antibodies) in primary lateral sclerosis
a novel brain gamma-secretase associated protein , erlin-2, that resides in detergent resistant membranes and affects amyloid beta-peptide production.
a novel role for ERLIN2 in supporting cancer cell growth by promoting the activation of the key lipogenic regulator SREBP1c (show SREBF1 Antibodies) and the production of cytosolic lipid droplets.
study describes an extended consanguineous Saudi family in which hereditary spastic paraplegia is linked to SPG18, an autosomal recessive locus, and show it is associated with a nullimorphic deletion of ERLIN2
Erlin-1 (show ERLIN1 Antibodies) and erlin-2 are novel members of the prohibitin (show PHB Antibodies) family of proteins that define lipid-raft-like domains of the ER.
SPFH2 as a key endoplasmic reticulum associated degradation pathway component and suggest that it may act as a substrate recognition factor.
Results suggest that this novel SPFH1 (show ERLIN1 Antibodies)/2 complex is a recognition factor that targets IP(3)Rs and perhaps other substrates for ERAD.
2 MDa erlin1 (show ERLIN1 Antibodies)/2 complex is composed of an assemblage of lower-order hetero-oligomers, probably heterotrimers, linked together by assembly domain hydrophobic residues.
This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, ER lipid raft associated 2
, SPFH domain family, member 2
, endoplasmic reticulum lipid raft-associated protein 2
, stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
, SPFH domain-containing protein 2