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The protein encoded by EGR1 belongs to the EGR family of C2H2-type zinc-finger proteins. Additionally we are shipping EGR1 Kits (41) and EGR1 Proteins (19) and many more products for this protein.
Showing 10 out of 134 products:
Cow (Bovine) Polyclonal EGR1 Primary Antibody for IHC, WB - ABIN2779517
Yu, de Belle, Liang, Adamson: Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. in Molecular cell 2004
Show all 7 references for ABIN2779517
Human Monoclonal EGR1 Primary Antibody for IF, WB - ABIN393945
Kim, Jeong, Jeong, Kim, Lee, Shin, Kye, Son: Cigarette smoke-induced Egr-1 represses T beta R-II expression in human skin dermal fibroblasts. in Toxicology 2010
Show all 5 references for ABIN393945
Human Monoclonal EGR1 Primary Antibody for WB - ABIN394244
Xu, Toure, Qu, Lin, Song, Shen, Rosario, Garcia, Schmidt, Yan: Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages. in The Journal of biological chemistry 2010
Show all 5 references for ABIN394244
Chimpanzee Polyclonal EGR1 Primary Antibody for EIA, IHC (p) - ABIN401280
Suggs, Katzowitz, Tsai-Morris, Sukhatme: cDNA sequence of the human cellular early growth response gene Egr-1. in Nucleic acids research 1990
Show all 3 references for ABIN401280
Human Monoclonal EGR1 Primary Antibody for ELISA, WB - ABIN969092
Chan, Lee, Ho, Wong, Lam, Tang, Chan, Abdullah, Wong, Lam: High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. in Clinica chimica acta; international journal of clinical chemistry 2009
Show all 2 references for ABIN969092
Human Polyclonal EGR1 Primary Antibody for FACS, IF - ABIN389442
Zhang, Chen, Wang, Guang, Han, Zhang, Tan, Gu: EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression. in Scientific reports 2014
Show all 2 references for ABIN389442
Human Polyclonal EGR1 Primary Antibody for WB - ABIN2774222
Akutagawa, Nishi, Kyo, Terauchi, Yamazawa, Higuma, Inoue, Isaka: Early growth response-1 mediates downregulation of telomerase in cervical cancer. in Cancer science 2008
Cow (Bovine) Polyclonal EGR1 Primary Antibody for IHC, WB - ABIN2779828
Schnell, Zoller, Patel, Williams, Kersh: Early growth response gene 1 provides negative feedback to inhibit entry of progenitor cells into the thymus. in Journal of immunology (Baltimore, Md. : 1950) 2006
Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.
Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
Data suggest that Egr-1 protein levels may be tightly regulated in an attempt to diminish neurotoxicity or to enhance plasticity in newborn animals.
we propose a model whereby high YB-1 levels in some TNBC cells can lead to reduced levels of EGR1, which in turn promotes slow cell cycling and resistance to PTX. Therefore YB-1 and EGR1 levels are biologically linked and may provide a biomarker for TNBC response to PTX.
TRAIL overexpression was co-regulated by Egr1 and Hypoxia response element. TRAIL might promote hypoxic A549 cell radiosensitivity and induce apoptosis depending on DR5 (show TNFRSF10B Antibodies) to caspase-3 (show CASP3 Antibodies) pathways.
These results suggest that frameshift mutations of EGR1 and BRSK1 (show BRSK1 Antibodies) might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer.
Pulmonary vascular Egr-1 expression is significantly increased in patients with PAH, appears specifically associated with neointimal-type vascular remodeling, and correlates with disease progression.
GRK2 (show ADRBK1 Antibodies) may inhibit IGF1 (show IGF1 Antibodies)-induced human hepatocellular carcinoma cell growth and migration through downregulation of EGR1.
did not find positive association signals of the four single nucleotide polymorphisms in the LAMA2 (show LAMA2 Antibodies) and EGR1 genes with high myopia
In nucleus pulposus cells early transcriptional programming initiated by EGR1 is essentially restrained by the cells' epigenome as it was determined during development and differentiation.
in primary cultures of glioma stemlike cells that EGR1 contributes to stemness marker expression and proliferation by orchestrating a PDGFA (show PDGFA Antibodies)-dependent growth-stimulatory loop.
The Egr-1 and Atg16L1 (show ATG16L1 Antibodies) genes' polymorphisms were significant risk factors for susceptibility to chronic obstructive pulmonary disease (COPD (show ARCN1 Antibodies)) . These results demonstrate that autophagy regulator genetic mutations are associated with COPD (show ARCN1 Antibodies) in male smokers.
IL-33 (show IL33 Antibodies)-ERK (show EPHB2 Antibodies)/JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies)/Egr-1/TSLP (show TSLP Antibodies) axis involved in allergic skin Th2 inflammation
Chronic hypoxia induces Egr-1 via activation of ERK1/2 (show MAPK1/3 Antibodies) and contributes to pulmonary vascular remodeling.
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
EGR1, an early growth response factor, is a critical transcription factor that regulates the hepatic clock circuit.
EGR1(-/-) mouse embryonic fibroblasts demonstrated lower susceptibility to Venezuelan equine encephalitis virus-induced cell death than isogenic wild-type fibroblasts, indicating that EGR1 modulates proapoptotic pathways following virus infection.
The levels of B23 (show NPM1 Antibodies) expression are directly regulated by EGR1.
our data demonstrate that the effect of FGF23 (show FGF23 Antibodies) on Pi homeostasis is mediated, at least in part, by activation of egr-1.
associated with this behavior, that is, an increase in the expression of the immediate early (show JUN Antibodies) gene Early Growth Response protein 1 (EGR1, Zif268)
Egr-1 is involved in NMDAR (show GRIN1 Antibodies)-mediated PSD-95 (show DLG4 Antibodies) down-regulation and AMPAR endocytosis, a process important in the expression of long term depression
ERG1 (show KCNH2 Antibodies) overexpression led to the development of highly aggressive B-cell malignancies.
EGR-1-induced GGPPS (show GGPS1 Antibodies) plays a vital role in the liver regeneration through the RAS/MAPK (show MAPK1 Antibodies) signaling.
Egr1 plays an important role in ischemia-reperfusion injury in lung transplants by regulating polymorphonuclear neutrophil infiltration.
Study indicated that ischemia-induced EGR1 expression may exaggerate brain injury by reducing BDNF (show BDNF Antibodies) expression
egr1 colocalizes with tyrosine hydroxylase (show TH Antibodies) in the olfactory bulb throughout brain development.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization
Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.
Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.
Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (show GDF7 Antibodies)/Smad1 (show SMAD1 Antibodies)/5/8 pathway.
Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (show CREB1 Antibodies)-mediated transactivation.
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
early growth response protein 1(Egr-1, NGFI-A)
, early growth response protein 1 (egr-1)
, early growth response 1
, early growth response protein 1
, nerve growth factor-induced protein A
, transcription factor ETR103
, transcription factor Zif268
, zinc finger protein 225
, zinc finger protein Krox-24
, Krox-24 nuclear protein
, zinc finger protein ZENK
, zinc-finger transcriptional protein
, early growth response protein 1-A