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Transcriptional regulator. Additionally we are shipping EGR4 Antibodies (30) and EGR4 Proteins (6) and many more products for this protein.
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EGR4 directly transactivates specific variants (V3 and V4) of the PTHrP (show PTHLH ELISA Kits) gene resulting in subsequent transactivation of the RANKL (show TNFSF11 ELISA Kits), IL-6 (show IL6 ELISA Kits) and IL-8 (show IL8 ELISA Kits) genes via paracrine action of the PTHrP (show PTHLH ELISA Kits) protein.
data suggest a tendency of gender-specific association of EGR2 (show EGR2 ELISA Kits) and EGR4 in schizophrenia.
Data found multiple differences in gene expression between the high and low infertility risk groups, confirming the importance of an intact hypothalamo-pituitary testicular axis and EGR4 in fertility development
Egr4 expression is triggered by trophic factor neurturin (show NRTN ELISA Kits) to upregulate K-Cl cotransporter (show SLC12A4 ELISA Kits) KCC2 (show SLC12A5 ELISA Kits) in immature neurons.
Egr4 is an important component in the mechanism of BDNF (show BDNF ELISA Kits)-dependent KCC2 (show SLC12A5 ELISA Kits) gene regulation via the ERK1/2 (show MAPK1/3 ELISA Kits) pathway in immature neurons.
Data suggest that Egr4 may regulate spermatogenesis at multiple steps, with roles in the dividing Sertoli cells, peritubular myoid (show MYO1A ELISA Kits) cells, and the meiotic and elongating haploid germ cell populations.
An important role for Egr4 is indicated in the developmental upregulation of potassium-chloride cotransporter (show SLC12A7 ELISA Kits) (KCC2 (show SLC12A5 ELISA Kits)) gene expression.
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
early growth response 4
, early growth response protein 4
, early response protein NGFI-C
, nerve growth factor-induced protein C
, zinc-finger transcription factor NGFI-C (early response gene)