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The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. Additionally we are shipping Egl Nine Homolog 2 (C. Elegans) Proteins (7) and many more products for this protein.
Showing 10 out of 125 products:
Human Polyclonal EGLN2 Primary Antibody for EM, ICC - ABIN151776
Li, Yi, Sundy, Chen, Hilliker, Donley, Muldoon, Li: Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. in American journal of physiology. Renal physiology 2007
Show all 36 references for ABIN151776
Human Polyclonal EGLN2 Primary Antibody for EIA, WB - ABIN952039
Winning, Splettstoesser, Fandrey, Frede: Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule-1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 2 references for ABIN952039
Human Polyclonal EGLN2 Primary Antibody for EIA, WB - ABIN453633
Semenza: HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. in Cell 2001
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Dog (Canine) Polyclonal EGLN2 Primary Antibody for WB - ABIN2778438
Pan, Mansfield, Bertozzi, Rudenko, Chan, Giaccia, Simon: Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. in Molecular and cellular biology 2007
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Human Polyclonal EGLN2 Primary Antibody for FACS, IHC (p) - ABIN652648
Aprelikova, Pandolfi, Tackett, Ferreira, Salnikow, Ward, Risinger, Barrett, Niederhuber: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. in Cancer research 2009
Chicken Polyclonal EGLN2 Primary Antibody for WB - ABIN2775992
Gilbert, Banek, Bauer, Gingery, Needham: Exercise training attenuates placental ischemia-induced hypertension and angiogenic imbalance in the rat. in Hypertension 2012
Dog (Canine) Polyclonal EGLN2 Primary Antibody for WB - ABIN2775821
Appelhoff, Tian, Raval, Turley, Harris, Pugh, Ratcliffe, Gleadle: Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. in The Journal of biological chemistry 2004
comparative analysis of phd1, 2, and 3 expression in Xenopus laevis
deleting Phd1-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.
These data identify PHD1 as a regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke.
PHD1 and PHD3 (show EGLN3 Antibodies) deletions promote angiogenesis in ischemia-injured tissue by increasing HIF1-alpha (show HIF1A Antibodies) stability.
Rosiglitazone increases PHD (show PDC Antibodies) expression in a PPARgamma (show PPARG Antibodies)-dependent manner and that this leads to the commitment of anti-adipogenic proteins to the ubiquitination-proteasomal pathway and to the subsequent induction of adipocyte differentiation.
PHD-1 deficient mouse appears to be the first animal model showing neuroepithelial bodies cell hyperplasia
Alterations in the function of all 3 isoforms of prolyl-4-hydroxylase enzymes (PHD1-3) in the first 24 h following transient focal cerebral ischaemia are reported.
Data show it is feasible to reactivate hepatic erythropoietin (show EPO Antibodies) production using systemically delivered siRNAs targeting the EglN1 (show EGLN1 Antibodies), EglN2 and EglN3 (show EGLN3 Antibodies) prolyl hydroxylase mRNA specifically in the liver.
silencing of PHD-1 attenuates myocardial ischemia/reperfusion injury probably by enhancing HIF-1alpha (show HIF1A Antibodies)/beta-catenin (show CTNNB1 Antibodies)/endothelial nitric oxide synthase (show NOS3 Antibodies)/nuclear factor-kappaB and Bcl-2 (show BCL2 Antibodies) signaling pathway
role for PHD1 as a positive regulator of intestinal epithelial cell apoptosis in the inflamed colon
Prolyl hydroxylase enzyme (PHD (show PDC Antibodies)) is the key enzyme responsible for degrading HIF-1 (show HIF1A Antibodies). HIF activation is an approach to increase vascularity and bone formation following skeletal trauma.
PHD1 is phosphorylated by CDK2 (show CDK2 Antibodies), CDK4 (show CDK4 Antibodies) and CDK6 (show CDK6 Antibodies) at Serine 130.
siRNA-mediated knockdown of PHD1 inhibited glucose-stimulated insulin (show INS Antibodies) secretion in pancreatic Beta cells.
EglN2 associates with the NRF1 (show NFE2L1 Antibodies)-PGC1alpha complex and controls mitochondrial function in breast cancer
rs3733829 in the EGLN2 gene is significantly associated with the risk of COPD (show ARCN1 Antibodies) in Chinese populations of Hainan province.
Germ-line PHD1 and PHD2 (show EGLN1 Antibodies) mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia
study conducted to investigate the association between gastric cancer (GC) susceptibility with a 4-bp insertion/deletion polymorphism (rs10680577) in the proximal promoter of EGLN2; findings showed that the heterozygote and the homozygote 4-bp del/del confer a significantly increased risk of GC
Data indicate that the prolyl hydrolase 1 (PHD1) rs10680577 polymorphism is associated with the risk of non-small cell lung cancer in a Chinese population.
PHD-1 played an important role in hypoxic response pathway of trophoblast through modulating the level of HIF-2alpha (show EPAS1 Antibodies).
PHD1 could induce cell cycle arrest in lung cancer cells, resulting in the suppression of cell proliferation.
Results show that variants in two adjacent genes, EGLN2 and CYP2A6 (show CYP2A6 Antibodies), influence smoking behavior related to disease risk.
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.
EGL nine homolog 2
, egl nine homolog 2
, Egl nine homolog 2
, EGL nine (C.elegans) homolog 2
, egl nine homolog 2 (C. elegans)
, egl nine homolog 2-like
, HIF-prolyl hydroxylase 1
, hypoxia-inducible factor prolyl hydroxylase 1
, immediate early response 4
, prolyl hydroxylase domain-containing protein 1
, HIF-1alpha prolyl-4-hydroxylase-1
, estrogen-induced tag 6