PHD1 antibody (AA 150-250)

Catalog No. ABIN1679676

The Rabbit Polyclonal anti-PHD1 antibody (ABIN1679676) specifically detects PHD1 in WB and IP. The antibody is reactive with Human samples.

Quick Overview for PHD1 antibody (AA 150-250) (ABIN1679676)

Target: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-PHD1 Antibody

Binding Specificity: AA 150-250

Sequence: MSCSCSSGSG EASAGLMEEA LPSAPERLAL DYIVPCMRYY GICVKDSFLG AALGGRVLAE VEALKRGGRL RDGQLVSQRA IPPRSIRGDQ IAWVEGHEPG C

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human Prolyl hydroxylase PHD1 (Prolyl hydroxylase PHD1 (EGLN2)) (NP_444274.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IP,1:20 - 1:50

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PHD1

Target: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Alternative Name: EGLN2

Background: The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.,EGLN2,EIT6,HIF-PH1,HIFPH1,HPH-1,HPH-3,PHD1,Epigenetics & Nuclear Signaling,Cancer,Invasion and Metastasis,Endocrine & Metabolism,Cardiovascular,Hypoxia,EGLN2

Molecular Weight: 40 kDa/43 kDa

Gene ID: 112398

UniProt: Q96KS0

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis