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Involved in the regulation of glucose homestasis and lipid metabolism (By similarity). Additionally we are shipping Energy Homeostasis Associated Antibodies (26) and Energy Homeostasis Associated Kits (13) and many more products for this protein.
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our data suggest that adropin is a membrane-bound protein that interacts with the brain-specific (show CALY Proteins) Notch1 (show NOTCH1 Proteins) ligand NB3 (show CNTN6 Proteins).
Release of adropin in the fed condition regulates fuel selection in skeletal muscle, promoting glucose oxidation over fat oxidation. The molecular mechanisms of adropin's effects involve acetylation (suggesting inhibition) of the transcriptional co-activator PGC1alpha, reducing PDK4 (show PDK4 Proteins) and CPT1B (show CPT1B Proteins) activity. Increased PGC1alpha acetylation by adropin may be mediated by inhibiting Sirtuin-1 (SIRT1 (show SIRT1 Proteins)), a PGC1alpha deacetylase.
Adropin has an endothelial protective function mediated via upregulation of eNOS expression through the VEGFR2-PI3K-Akt and VEGFR2-ERK1/2 pathways. (show KDR Proteins)Adropin therapy may thus be useful (show AKT1 Proteins) for limiti (show KDR Proteins)ng diseases characterized by endothelial d (show MAPK3 Proteins)ysfunction.
Adropin is the name given to the secreted peptide encoded by human C9orf165. In mice, it is abundant in liver where it is regulated by dietary macronutrients. Adropin regulates expression of genes involved in lipogenesis and adipogenesis.
In HD patients, lower plasma adropin concentration is associated with dyslipidemia. Major homozygosity of RXRA (show RXRA Proteins) seems to have an opposite effect on plasma adropin compared with that of ENHO rs2281997
Data suggest that serum adropin (ENHO) levels in normal, overweight, and obese adults negatively correlate with vascular stiffness (using common carotid artery) and adiposity (using abdominal visceral fat), and positively correlate with plasma nitric oxide levels (using nitrite/nitrate) and cardiorespiratory fitness; aerobic exercise training up-regulates serum adropin.
The adropin levels of metabolic syndrome, obesity, and control groups also showed no difference
Circulating adropin levels were determined lower in patients with endometrial cancer than in a control group.
Lipids originating either from the diet or from endogenous production appear to positively affect plasma adropin concentrations in humans.
Serum adropin levels were significantly lower in obese children; however, there was no correlation between serum adropin levels and blood pressure variables.
Adropin as a novel energy factor likely has the ability to regulate blood pressure
Serum adropin level was negatively correlated with carotid beta-stiffness and positively correlated with plasma NOx level and cardiorespiratory fitness
Adropin levels are lower in patients with late saphenous vein graft occlusion and these reduced adropin levels, together with other factors, may lead to saphenous vein graft occlusion
decreased serum adropin levels are associated with the presence of acute myocardial infarction in coronary artery disease patients
Involved in the regulation of glucose homestasis and lipid metabolism (By similarity).
, energy homeostasis-associated protein
, energy homeostasis associated
, energy homeostasis associated protein