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In the process of mRNA degradation, seems to play a role in mRNA decapping (By similarity). Additionally we are shipping EDC4 Antibodies (35) and EDC4 Kits (3) and many more products for this protein.
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Seedling lethal phenotypes in dcp1 (show ACE Proteins), dcp2 (show DCP2 Proteins) and vcs mutants are caused the disruption of miRNA-mediated gene regulation.
DCP2 (show DCP2 Proteins) interacts in vitro and in vivo with DCP1 (show ACE Proteins) and VARICOSE (VCS), an Arabidopsis homolog of human Hedls/Ge-1, suggesting that the three proteins operate as a decapping complex.
The assembly of EDC4 and Dcp1a (show DCP1A Proteins) into processing bodies is critical for the translational regulation of IL-6 (show IL6 Proteins).
LMKB is the first protein identified to date that interacts with this portion of Ge-1. LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L (show IFI44L Proteins).
EDC4 is a processing body (P-body) component.
The data indicates that DCP2 (show DCP2 Proteins) activation by DCP1 (show ACE Proteins) occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 (show DCP2 Proteins) activation by DCP1 (show ACE Proteins) with 5'-to-3' mRNA degradation by XRN1 (show XRN1 Proteins) in human cells.
EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies
Ge-1, the human ortholog of mouse Edc4, was shown to localize to mRNA processing bodies (P-body)in a human cell line. The C-terminal region is required for this localization.
The human Ge-1 gene (also known as Hedls and Edc4)is an ortholog of mouse Edc4. The gene was identified by screening a cDNA expression library using serum from a patient with Sjogren's syndrome.
In the process of mRNA degradation, seems to play a role in mRNA decapping (By similarity).
enhancer of mRNA decapping 4
, autoantigen Ge-1
, autoantigen RCD-8
, enhancer of mRNA-decapping protein 4
, human enhancer of decapping large subunit
, autoantigen RCD8