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Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 Proteins (EIF2AK2)

The protein encoded by EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. Additionally we are shipping EIF2AK2 Antibodies (259) and EIF2AK2 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF2AK2 5610 P19525
EIF2AK2 19106 Q03963
Rat EIF2AK2 EIF2AK2 54287 Q63184
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Top EIF2AK2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

EIF2AK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) Interaction Partners

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) interaction partners

  1. the expression of a Tat (show TAT Proteins) construct containing mutations in the basic region (49-57aa), which is responsible for the interaction with PKR (show PKLR Proteins), favored neither parasite growth nor IL-10 (show IL10 Proteins) expression in infected macrophages.

  2. This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (show NIPBL Proteins) and HDAC8 (show HDAC8 Proteins) mutations and PKR (show PKLR Proteins) activation.

  3. The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (show EIF2S1 Proteins), which is mediated by continual activation of PKR (show PKLR Proteins) and degradation of PP1 (show PPA1 Proteins).

  4. The sole essential function of cytomegalovirus TRS1 is to antagonize host PKR (show PKLR Proteins).

  5. results show that ceramide acts at two distinct levels of the insulin (show INS Proteins) signaling pathway (IRS1 (show IRS1 Proteins) and Akt (show AKT1 Proteins)). PKR (show PKLR Proteins), which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (show INS Proteins) resistance in muscle cells.

  6. Classical swine fever virus (CSFV) infection increased the phosphorylation of eukaryotic translation initiation factor (show EIF2A Proteins) (eIF)2alpha (show EIF2S1 Proteins) and its kinase PKR (show PKLR Proteins). The activation of PKR (show PKLR Proteins) during CSFV infection is beneficial to the virus.

  7. these data indicate a pivotal role for PKR's protein-binding function on the proliferation of pancreatic beta cells through TRAF2 (show TRAF2 Proteins)/RIP1 (show UQCRFS1 Proteins)/NF-kappaB (show NFKB1 Proteins)/c-Myc (show MYC Proteins) pathways.

  8. The results from this study indicate an important role of RAX (show RAX Proteins)/PKR (show PKLR Proteins) association in regulating PKR (show PKLR Proteins) activity as well as ethanol neurotoxicity

  9. The G3BP1 (show G3BP1 Proteins)-Caprin1-PKR (show PKLR Proteins) complex represents a new mode of PKR (show PKLR Proteins) activation and is important for antiviral activity of G3BP1 (show G3BP1 Proteins) and PKR (show PKLR Proteins) during infection with mengovirus.

  10. The data support a model in which activating RNAs induce formation of a back-to-back parallel PKR (show PKLR Proteins) kinase dimer whereas nonactivating RNAs either fail to induce dimerization or produce an alternative, inactive dimer configuration.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) interaction partners

  1. This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (show NIPBL Proteins) and HDAC8 (show HDAC8 Proteins) mutations and PKR activation.

  2. Deletion of PKR does not affect HFD-induced obesity, hepatic steatosis or glucose metabolism, and only modestly affects adipose tissue inflammation.

  3. results show that ceramide acts at two distinct levels of the insulin (show INS Proteins) signaling pathway (IRS1 (show IRS1 Proteins) and Akt (show AKT1 Proteins)). PKR, which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (show INS Proteins) resistance in muscle cells.

  4. Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (show CDK7 Proteins) R) functions as negative regulator of PKR/Eif2ak2 (protein kinase (show CDK7 Proteins) R) in development of postnatal anterior pituitary tissue.

  5. Data indicate increasing expression of PKR during TNF-a (show TNF Proteins)-induced osteoclast formation. Its inhibition prevents TNF-a (show TNF Proteins)-induced bone destruction in vivo and can be then considered as new therapeutic target for bone disease.

  6. The authors show that Murine cytomegalovirus m142 and m143 knockout mutants attain organ titers equivalent to those attained by wild-type virus in Pkr knockout mice.

  7. these data indicate a pivotal role for PKR's protein-binding function on the proliferation of pancreatic beta cells through TRAF2 (show TRAF2 Proteins)/RIP1 (show RALBP1 Proteins)/NF-kappaB (show NFKB1 Proteins)/c-Myc (show MYC Proteins) pathways.

  8. Activated PKR inhibits pancreatic beta-cell proliferation through sumoylation-dependent stabilization of P53 (show TP53 Proteins).

  9. These data indicate that the association between PKR and TRBP integrates metabolism with translational control and inflammatory signaling and plays important roles in metabolic homeostasis and disease.

  10. The age-associated accumulation of somatic mutations that occurs in the Nup98 (show NUP98 Proteins)-HOXD13 (show HOXD13 Proteins) (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR transgene.

EIF2AK2 Protein Profile

Protein Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with EIF2AK2

  • eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2)
  • eukaryotic translation initiation factor 2-alpha kinase 2 (eif2ak2)
  • eukaryotic translation initiation factor 2-alpha kinase 2 (Eif2ak2)
  • 2310047A08Rik protein
  • 4732414G15Rik protein
  • AI467567 protein
  • AI747578 protein
  • DKFZp469K1934 protein
  • EIF2AK1 protein
  • EIF2AK2 protein
  • Pkr protein
  • Prkr protein
  • Tik protein

Protein level used designations for EIF2AK2

double-stranded RNA-activated protein kinase , interferon-induced, double-stranded RNA-activated protein kinase , p68 kinase , P1/eIF-2A protein kinase , interferon-inducible RNA-dependent protein kinase , IFN-stimulated dsRNA-activated eIF2-alpha kinase 2 , double-stranded RNA activated protein kinase , eukaryotic translation initiation factor 2-alpha kinase 2 , double stranded RNA activated protein kinase , eIF-2A protein kinase 2 , interferon-inducible elF2alpha kinase , protein kinase, interferon-inducible double stranded RNA dependent , tyrosine-protein kinase EIF2AK2 , IFN- type I-induced and dsRNA-activated kinase , IFN-induced and double-stranded RNA-activated kinase , T-cell viral integration site , dsRNA-activated kinase , eIF-2 alpha , eukaryotic translation initiation factor 2 alpha kinase 2 , protein kinase RNA-activated , protein kinase, interferon inducible double stranded RNA dependent , serine/threonine-protein kinase TIK , Protein kinase, interferon-inducible double stranded RNA dependent

GENE ID SPECIES
395147 Gallus gallus
459155 Pan troglodytes
611397 Canis lupus familiaris
708912 Macaca mulatta
100001092 Danio rerio
100009013 Oryctolagus cuniculus
100147679 Equus caballus
100173054 Pongo abelii
100579484 Nomascus leucogenys
5610 Homo sapiens
19106 Mus musculus
54287 Rattus norvegicus
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