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EIF2B5 encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Additionally we are shipping EIF2B5 Antibodies (30) and many more products for this protein.
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These results reveal a key role of the AKT (show AKT1 Proteins)-GSK3beta-eIF2Bepsilon signaling module in regulating axon regeneration in the adult mammalian central nervous system.
analysis of eukaryotic initiation factor 2B epsilon phosphorylation sites and ubiquitin-modified lysine residues
Data show that toll (show TLR4 Proteins)-like receptors (TLRs)-TRIF (show RNF138 Proteins) signalling activates eIF2B (show EIF2B4 Proteins) GEF (show ARHGEF2 Proteins) through PP2A (show PPP2R2B Proteins)-mediated serine dephosphorylation of the eIF2B (show EIF2B4 Proteins) varepsilon-subunit.
mouse model of EIF2B (show EIF2B4 Proteins)-related leukodystrophy; findings provide evidence that hypomorphic Eif2b5 alleles lead to delayed and abnormal development and maintenance of CNS white matter
Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha (show EIF2A Proteins) phosphorylation, reduction of eIF2B (show EIF2B4 Proteins) activity, and inhibition of eIF4F (show EIF4A2 Proteins) complex formation.
inactivation of glycogen synthase kinase 3beta (GSK3beta) by high glucose and high insulin (show INS Proteins) induces increase in synthesis of laminin beta1 via activation of eIF2Bepsilon.
Exon-level analyses classified > 1,000 mRNAs as alternatively spliced under hypoxia and uncovered a unique retained intron (RI) in the master regulator of translation initiation, EIF2B5.
This study demonstrated that no evidence for a role of Ile587Val polymorphism of EIF2B5 gene in multiple sclerosis in Kashmir Valley if India.
Patient exhibits an early-infantile onset and progressive disease course resembling Cree leukoencephalopathy, suggesting a severe functional disruption of eIF2Bepsilon caused by R195H as well as by I408T mutations.
Missense mutations in EIF2B5 are associated with multiple sclerosis.
Also a mutation c.1913G>A[p.Arg638 His] in exon 14 of the EIF2B5-Gens as single nucleotide polymorphism.
crystal structure of the guanine nucleotide exchange factor (show RASGRF1 Proteins) for elf2 (show ELF2 Proteins)
Functional analysis of recently identified mutations in eukaryotic translation initiation factor (show EIF2A Proteins) 2Bepsilon (eIF2Bepsilon) identified in Chinese patients with vanishing white matter disease
Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus.
Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy.
We demonstrated that mutations in the gene EIF2B5 cause "leukoencephalopathy with vanishing white matter." This gene encodes one of the five subunits of the translation factor eIF2B (show EIF2B1 Proteins).
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
, translation initiation factor eIF-2B subunit epsilon
, translation initiation factor eIF-2B subunit epsilon-like
, translation initiation factor eIF-2B epsilon subunit
, translation initiation factor eif-2b epsilon subunit
, eIF-2B GDP-GTP exchange factor subunit epsilon
, initiation factor eIF-2Be