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Eukaryotic Translation Initiation Factor 4A1 Proteins (EIF4A1)

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. Additionally we are shipping EIF4A1 Antibodies (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF4A1 1973 P60842
EIF4A1 13681 P60843
Rat EIF4A1 EIF4A1 287436  
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Top EIF4A1 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,102.00
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
Yeast Human Un-conjugated   100 μg Log in to see 5 to 9 Days
$369.79
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

EIF4A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Mouse (Murine)

More Proteins for Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Interaction Partners

Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) interaction partners

  1. Studies indicate a developing focus on targeting eukaryotic initiation factor 4A (show DDX39 Proteins) eIF4A1 and eIF4A2 (show EIF4A2 Proteins) as cancer therapy.

  2. Immunohistochemical analysis was performed on over 3000 breast tumors to investigate the relationship among expression of eIF4A1, the helicase-modulating proteins eIF4B (show EIF4B Proteins), eIF4E (show EIF4E Proteins) and PDCD4 (show PDCD4 Proteins), and clinical outcome.

  3. Collectively, these data suggested that a potential role of NS4A in antagonizing host antiviral defense is by recruiting eIF4AI and escaping the translation inhibition mediated by PKR (show PKLR Proteins).

  4. eIF4A functions as an adenosine triphosphate-dependent processive helicase when complexed with two accessory proteins, eIF4G (show EIF4G1 Proteins) and eIF4B (show EIF4B Proteins).

  5. demonstrate that DAP5 associates with eIF2beta and eIF4AI to stimulate IRES-dependent translation of cellular mRNAs

  6. Studies indicate that eukaryotic initiation factor 4AI (EIF4AI) undergoes large conformational transitions, while unwinding RNA hairpins.

  7. Data indicate that caspase (show CASP3 Proteins) recruitment domain family, member 11 protein CARD11 (show CARD11 Proteins) has complex 5'UTRs and is sensitive to eIF4A RNA helicase inhibition.

  8. Increased Expression of EIF4A1 is associated with poor response to Brachytherapy in Cervical Cancer.

  9. report of an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of silvestrol and related compounds

  10. The E186 residue was found to be of significance for RNA-dependent ATPase activity for eIF4AI alone and in the presence of eIF4AI-binding domains of eIF4GI (show EIF4G1 Proteins), binding between eIF4AI and eIF4GI (show EIF4G1 Proteins) domains were also significantly influenced by mutation of E186.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) interaction partners

  1. the central A-rich domains of BC RNAs target eIF4A, specifically inhibiting its RNA helicase activity

  2. analysis of the tandem MA-3 (show PDCD6 Proteins) region of Pdcd4 (show PDCD4 Proteins) protein and characterization of its interactions with eIF4A and eIF4G (show EIF4G1 Proteins)

  3. Pdcd4 (show PDCD4 Proteins) binding to eIF4A is linked to its transformation-suppressing activity, as Pdcd4 (show PDCD4 Proteins)-eIF4A binding and consequent inhibition of translation are required for Pdcd4 (show PDCD4 Proteins) transrepression of AP-1 (show JUN Proteins).

  4. The binding of pateamine to eIF4A presets the protein in the high-affinity RNA-binding state, which stimulates ATP binding, hydrolysis, and RNA unwinding.

  5. interactions between Pdcd4 (show PDCD4 Proteins) and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G (show EIF4G1 Proteins)

  6. analysis of cells of eIF4GIf molecules lacking either the PABP (show EBP Proteins)-binding site, the eIF3 (show EIF3A Proteins)-binding site, the middle domain eIF4A-binding site, or the C-terminal segment that includes the second eIF4A-binding site

EIF4A1 Protein Profile

Protein Summary

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).

Gene names and symbols associated with EIF4A1

  • eukaryotic translation initiation factor 4A1 (eif4a1)
  • eukaryotic translation initiation factor 4A1 (EIF4A1)
  • eukaryotic translation initiation factor 4A, isoform 1 (EIF4A1)
  • eukaryotic translation initiation factor 4A1 (Eif4a1)
  • BM-010 protein
  • Ddx2a protein
  • EIF-4A protein
  • eIF-4A-I protein
  • Eif4 protein
  • EIF4A protein
  • eIF4A-I protein

Protein level used designations for EIF4A1

translation initiation factor eIF4A I , eukaryotic translation initiation factor 4A1 , eukaryotic translation initiation factor 4A, isoform 1 , eukaryotic translation initiation factor 4A , eukaryotic initiation factor 4A-I , eukaryotic translation initiation factor 4A-like , eukaryotic initiation factor 4A-I-like , ATP-dependent RNA helicase eIF4A-1 , eIF-4A-I , eIF4A-I , eukaryotic initiation factor 4AI , initiation factor eIF-4A long form

GENE ID SPECIES
443739 Xenopus laevis
479485 Canis lupus familiaris
496556 Xenopus (Silurana) tropicalis
100061902 Equus caballus
100101929 Sus scrofa
100355889 Oryctolagus cuniculus
100388544 Callithrix jacchus
100582095 Nomascus leucogenys
748995 Pan troglodytes
1973 Homo sapiens
13681 Mus musculus
287436 Rattus norvegicus
695050 Macaca mulatta
100173783 Pongo abelii
100688577 Canis lupus familiaris
504958 Bos taurus
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