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Eukaryotic Translation Initiation Factor 4B Proteins (EIF4B)

Required for the binding of mRNA to ribosomes. Additionally we are shipping EIF4B Antibodies (175) and EIF4B Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF4B 1975 P23588
EIF4B 75705 Q8BGD9
Rat EIF4B EIF4B 300253  
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Top EIF4B Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

EIF4B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced EIF4B Proteins

  1. Human EIF4B Protein expressed in Wheat germ - ABIN1352593 : Chen, Lin, Chow, Lee: Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells. in Proteomics 2011 (PubMed)
    Show all 2 references for ABIN1352593

More Proteins for Eukaryotic Translation Initiation Factor 4B (EIF4B) Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4B (EIF4B) interaction partners

  1. Data show that two functionally redundant isoforms of Drosophila eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation.

Human Eukaryotic Translation Initiation Factor 4B (EIF4B) interaction partners

  1. MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B.

  2. S6K1 (show RPS6KB1 Proteins) enhances c-Myc (show MYC Proteins) translation efficiency by modulating the phosphorylation of eukaryotic initiation factor (show EIF4G1 Proteins) eIF4B, which is critical to unwind its structured 5' untranslated region.

  3. EIF4B, as a potentially key fragile point in EGFR (show EGFR Proteins) and mTOR (show FRAP1 Proteins) inhibitor synergy.

  4. eIF4B is the RSK (show RPS6KA1 Proteins) downstream effector responsible for elevated Lamgamma2 as well as MYC (show MYC Proteins) protein in neoplastic epithelial cells.

  5. The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus.

  6. eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX (show DAXX Proteins) and ERCC5 (show ERCC5 Proteins) are identified as novel prognostic markers for poor survival in DLBCL

  7. Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain.

  8. Overexpression of pim-2 (show PIM2 Proteins) may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis.

  9. our results identify eIF4B as a critical substrate of Pim (show PIM1 Proteins) kinases in mediating the activity of Abl (show ABL1 Proteins) oncogenes

  10. ORF45/RSK (show RPS6KA1 Proteins) axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4B (EIF4B) interaction partners

  1. PKR (show EIF2AK2 Proteins) inhibition reduced the expression of eIF4B and C/EBPbeta (show CEBPB Proteins) in an eIF2alpha (show EIF2A Proteins)-independent manner

  2. Maintenance of eIF4E (show EIF4E Proteins) interaction with eIF4G (show EIF4G1 Proteins) was not by itself sufficient to sustain global rates of protein synthesis in the absence of mTORC1 signaling to p70S6K1 (show RPS6KB1 Proteins); phosphorylation of both eIF4B and PDCD4 (show PDCD4 Proteins) was additionally required.

  3. C-loops bind to eIF4B and prevent the factor's interaction with 18S rRNA of the small ribosomal subunit.

  4. Phosphorylation of eIF4B on Ser422 by p90 (show GPAM Proteins) ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) (RSK (show RPS6KA1 Proteins)) and S6K (show RPS6KB1 Proteins) is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3 (show EIF4E3 Proteins).

  5. These data provide novel insights into complex multikinase regulation of eIF4B phosphorylation and reveal an important mechanism by which PKB (show AKT2 Proteins) can regulate translation, potentially critical for the transforming capacity of this AGC (show ACAN Proteins) kinase family member.

  6. Results establish critical roles for S6K (show RPS6KB1 Proteins) and RSK (show RPS6KA1 Proteins) in the induction of IFN-dependent biological effects and define a key regulatory role for eIF4B as a common mediator and integrator of IFN-generated signals from these kinases.

EIF4B Protein Profile

Protein Summary

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Gene names and symbols associated with EIF4B

  • eukaryotic translation initiation factor 4B (EIF4B)
  • eukaryotic initiation factor 4B (Eif4B)
  • Eukaryotic initiation factor 4B (eIF-4B)
  • eukaryotic translation initiation factor 4Bb (eif4bb)
  • eukaryotic translation initiation factor 4B (eif4b)
  • eukaryotic translation initiation factor 4Ba (eif4ba)
  • eukaryotic translation initiation factor 4B (LOC100284982)
  • Eukaryotic translation initiation factor 4B (if4b)
  • eukaryotic translation initiation factor 4B (Eif4b)
  • 2310046H11Rik protein
  • AL024095 protein
  • C85189 protein
  • CG10837 protein
  • DKFZp469D171 protein
  • Dm-eIF4B protein
  • Dmel\\CG10837 protein
  • eIF-4b protein
  • eIF-4B-L protein
  • eIF-4B-S protein
  • Eif4a2 protein
  • EIF4B protein
  • eIF4B-L protein
  • eIF4B-S protein
  • fb15c09 protein
  • MGC89384 protein
  • PRO1843 protein
  • wu:fb15c09 protein
  • zgc:101532 protein

Protein level used designations for EIF4B

eukaryotic initiation factor 4B , CG10837-PA , CG10837-PB , CG10837-PE , CG10837-PF , eIF-4B-PA , eIF-4B-PB , eIF-4B-PE , eIF-4B-PF , eukaryotic translation initiation factor 4B , hypothetical protein , Eukaryotic translation initiation factor 4B , eIF-4B

GENE ID SPECIES
100061920 Equus caballus
543417 Triticum aestivum
3355041 Drosophila melanogaster
100401147 Callithrix jacchus
336619 Danio rerio
448618 Xenopus (Silurana) tropicalis
553214 Danio rerio
737509 Pan troglodytes
100037232 Xenopus laevis
100173344 Pongo abelii
100284982 Zea mays
100380867 Salmo salar
1975 Homo sapiens
505850 Bos taurus
75705 Mus musculus
300253 Rattus norvegicus
100858349 Gallus gallus
477600 Canis lupus familiaris
100735681 Cavia porcellus
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