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Eukaryotic Translation Initiation Factor 5A Proteins (EIF5A)

EIF5A encodes an elongation initiation factor, which participates in protein synthesis. Additionally we are shipping Eukaryotic Translation Initiation Factor 5A Antibodies (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF5A 1984 P63241
EIF5A 276770 P63242
EIF5A 287444 Q3T1J1
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Top Eukaryotic Translation Initiation Factor 5A Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$437.80
Details
Yeast Schistosoma mansoni His tag   1 mg Log in to see 56 to 66 Days
$2,025.83
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,339.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,339.33
Details
Yeast Nicotiana tabacum His tag   1 mg Log in to see 56 to 66 Days
$2,357.67
Details
Yeast REACT_Tobacco His tag   1 mg Log in to see 56 to 66 Days
$2,357.67
Details

EIF5A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Eukaryotic Translation Initiation Factor 5A Proteins

  1. Human EIF5A Protein expressed in Escherichia coli (E. coli) - ABIN666636 : Gosslau, Jao, Butler, Liu, Chen: Thermal killing of human colon cancer cells is associated with the loss of eukaryotic initiation factor 5A. in Journal of cellular physiology 2009 (PubMed)
    Show all 2 references for ABIN666636

More Proteins for Eukaryotic Translation Initiation Factor 5A (EIF5A) Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 5A (EIF5A) interaction partners

  1. Results describe the identification and characterization of nero, the Drosophila melanogaster deoxyhypusine hydroxylase (DOHH) homologue, and indicate that nero and eIF5A are required for cell growth and affect autophagy and protein synthesis.

Maize/Corn (Zea mays) Eukaryotic Translation Initiation Factor 5A (EIF5A) interaction partners

  1. phosphorylation of Ser(2) plays a role in regulation of nucleocytoplasmic shuttling of eIF5A in plant cells

Human Eukaryotic Translation Initiation Factor 5A (EIF5A) interaction partners

  1. Our results suggest that functional, hypusinated eIF5A (show EIF5 Proteins) is necessary for HIF-1alpha (show HIF1A Proteins) expression during hypoxia and that eIF5A (show EIF5 Proteins) is an attractive target for cancer therapy.

  2. findings also implicate the eIF5A (show EIF5 Proteins)/RhoA (show RHOA Proteins)/ROCK module as a potential new therapeutic target to treat metastatic PDAC cells

  3. eIF5A (show EIF5 Proteins) has been shown to regulate a number of gene products specifically, termed the eIF5A (show EIF5 Proteins) regulon, and its role in translating proline-rich sequences has recently been identified.

  4. eIF5A (show EIF5 Proteins) proteins utilize PEAK1 (show PEAK1 Proteins) as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis.

  5. Mature eIF5A (show EIF5 Proteins) (hypusinated form) is not involved in the autophagic pathway.

  6. The findings that eIF5A (show EIF5 Proteins) and EF-P are important for specific cellular processes and play a role in the relief of ribosome stalling caused by specific amino acid sequences

  7. Data suggest a regulatory mechanism for the pro-apoptotic protein eukaryotic translation initiation factor 5A1 (eIF5A1) in which its level is possibly modulated by NF-kappaB (show NFKB1 Proteins) in lung cells.

  8. Data indicate that the signal of EIF5A2 (show EIF5A2 Proteins), MYCN (show MYCN Proteins), and MCL1 (show MCL1 Proteins) genes is decreased in hydroxyurea (HU) and gemcitabine (GEM (show GEM Proteins)) treated UACC-1598 ovarian cancer cell line.

  9. mature eIF5A (show EIF5 Proteins) controls a translational network of cancer-driving genes, termed the eIF5A (show EIF5 Proteins) regulon, at the levels of mRNA abundance and translation

  10. The expression of eIF5A (show EIF5 Proteins)-2 was up-regulated following EMT (show ITK Proteins) phenotype changes in A549 cells, which correlated with enhanced tumor invasion and metastatic capabilities.

Mouse (Murine) Eukaryotic Translation Initiation Factor 5A (EIF5A) interaction partners

  1. our results provide the first genetic evidence that the hypusine modification in eIF-5A is crucial for homeostasis in mammals

  2. knockout of either the eIF5A-1 gene (Eif5a) or of the deoxyhypusine synthase (show DHPS Proteins) gene (Dhps (show DHPS Proteins)) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxyhypusine synthase (show DHPS Proteins) in mammalian development

  3. These results point to a new functional role for eIF5A, relating it to embryogenesis, development, and cell differentiation.

  4. a decrease in either active eIF5A or polyamines inhibits cell growth, indicating that eIF5A and polyamines are independently involved in cell growth

  5. Results indicate that the N-terminal extension of the eukaryotic eIF5A contributes in signaling this protein to nuclear localization, despite of bearing no structural similarity with classical nuclear localization signals.

  6. Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys (show LYZ Proteins) 50. Mouse EIF5A1 and EIF5A2 (show EIF5A2 Proteins) encode two isoforms: eIF5AI and eIF5AII (show EIF5A2 Proteins).

Cow (Bovine) Eukaryotic Translation Initiation Factor 5A (EIF5A) interaction partners

  1. The deduced bovine eIF5A protein is 100% identical to human Eif5A.

Eukaryotic Translation Initiation Factor 5A (EIF5A) Protein Profile

Protein Summary

This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19.

Gene names and symbols associated with EIF5A

  • CG3186 gene product from transcript CG3186-RA (eIF-5A)
  • eukaryotic translation initiation factor 5A (eif5a)
  • eukaryotic translation initiation factor 5A (tif5A)
  • eukaryotic translation initiation factor 5a (Tb11.03.0410)
  • initiation factor 5a (AaeL_AAEL003835)
  • putative eukaryotic initiation factor 5a (EIF5A1)
  • eukaryotic translation initiation factor 5A (EIF5A)
  • eukaryotic translation initiation factor 5A (Eif5a)
  • eukaryotic translation initiation factor 5A-like (LOC100338341)
  • eukaryotic translation initiation factor 5A-like 1 (LOC100353344)
  • 1296 protein
  • AA410058 protein
  • anon-EST:fe2H10 protein
  • CG3186 protein
  • D19Wsu54e protein
  • DDBDRAFT_0191442 protein
  • DDBDRAFT_0218663 protein
  • DDB_0191442 protein
  • DDB_0218663 protein
  • Dmel\\CG3186 protein
  • eIF-4D protein
  • eIF-5A protein
  • eIF-5A-1 protein
  • eIF-5A1 protein
  • Eif4d protein
  • eIF5a protein
  • Eif5a1 protein
  • eIF5AI protein
  • l(2)01296 protein
  • wu:fb17e01 protein
  • wu:fb63h04 protein
  • wu:fk81e04 protein
  • zgc:77099 protein

Protein level used designations for EIF5A

CG3186-PA , CG3186-PB , anon-fast-evolving-2H10 , eIF-5A-PA , eIF-5A-PB , eukaryotic initiation factor 5A , eukaryotic translation factor 5A , eukaryotic translation initiation factor 5A-1 , eukaryotic translation initiation factor 5A , csu154 , csu175 , csu203 , eIF-4D , eIF-5A , SOG0075 , csu154b , umc384c , S1_eIF5A , csu154c(eif5A) , csu175d(eif5A) , csu203a(eif5A) , translation initiation factor 5A , eukaryotic translation initiation factor 5a , initiation factor 5a , putative eukaryotic initiation factor 5a , eIF-5A-1 , eIF-5A1 , rev-binding factor

GENE ID SPECIES
37846 Drosophila melanogaster
406464 Danio rerio
542601 Zea mays
3665847 Trypanosoma brucei brucei strain 927/4 GUTat10.1
8624890 Dictyostelium discoideum AX4
5579111 Aedes aegypti
5069539 Leishmania infantum JPCM5
10966659 Leishmania infantum JPCM5
1984 Homo sapiens
276770 Mus musculus
287444 Rattus norvegicus
444990 Bos taurus
100338341 Oryctolagus cuniculus
100353344 Oryctolagus cuniculus
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