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NEDD4L encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. Additionally we are shipping Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Antibodies (62) and many more products for this protein.
Showing 4 out of 6 products:
overexpression of miR (show MLXIP Proteins)-93 in lung cancer cells promoted TGF-b-induced EMT (show ITK Proteins) through downregulation of NEDD4L. The analysis of publicly available gene expression array datasets indicates that low NEDD4L expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR (show MLXIP Proteins)-93 in lung tumorigenesis and metastasis.
the regulation of Nedd4L protein expression may play a role in the development of ovarian cancers.
Propose regulation of placental SNAT2 (show SLC38A2 Proteins)/LAT1 (show LAT Proteins) ubiquitination by mTORC1 and Nedd4-2.
Overexpression of Nedd4-2 enhanced hOAT4 (show SLC22A9 Proteins) ubiquitination, and inhibited hOAT4 (show SLC22A9 Proteins) transport activity.
Our results suggest that three screened NEDD4-2 variants do not play a leading role in the pathogenesis of photosensitive epilepsy in the Turkish population.
The mechanisms of activation and degradation of the NEDD4L:the transition from the closed to the active form is regulated by a competition of inositol 1,4,5-trisphosphate and Ca2 (show CA2 Proteins)+.
Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.
Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.
DDB2 (show DDB2 Proteins) can bind to the promoter region of NEDD4L and recruit enhancer of zeste homolog 2 (show EZH2 Proteins) histone methyltransferase to repress NEDD4L transcription by enhancing histone H3 (show HIST3H3 Proteins) lysine 27 trimethylation at the NEDD4L promoter.
These results suggested that the functional variant of NEDD4L, rs4149601, may be associated with obesity and related phenotypes, and further genetic and functional studies are required to understand its role in the manifestation of obesity.
these findings suggest that regulation of Dvl (show DVL2 Proteins) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.
Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Proteins)-activated kinase promotes ENaC (show SCNN1A Proteins)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Proteins) by increasing Nedd4-2-dependent ENaC (show SCNN1A Proteins) retrieval from the plasma membrane.
results indicate that AMPK (show PRKAA2 Proteins) inhibits KCNQ1 (show KCNQ1 Proteins) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.
This study suggested that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo.
ENaC-beta (show SCNN1B Proteins) regulation that occurs through IKKbeta (show IKBKB Proteins)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Proteins) and protein kinase A target site.
These findings elucidate a critical role of Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins)-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.
We identified glutamate (show GRIN1 Proteins) receptor subunit 1 (GluA1 (show GRIA1 Proteins)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2
The short isoform of the ubiquitin ligase (show RNF123 Proteins) NEDD4L is a CREB (show CREB1 Proteins) target gene in hepatocytes.
Nedd4-2-mediated ubiquitination of beta-ENaC (show SCNN1B Proteins) leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.
The first physiological evidence for an essential function of Nedd4-2 in regulating voltage-gated sodium channels in the central nervous system.
NEDD4-2 is a potent posttranslational regulator of voltage-gated sodium channels.
loss of NEDD4-2 in adult renal tubules causes a new form of mild, salt-sensitive hypertension without hyperkalemia that is characterized by upregulation of NCC (show SLC12A3 Proteins), elevation of beta/gammaENaC (show SCNN1G Proteins), but not alphaENaC (show SCNN1A Proteins), and a normal Na+/K+ balance
Neural precursor cell-expressed developmentally down-regulated protein 4 (show NEDD4 Proteins)-2 (Nedd4-2) regulation by 14-3-3 protein (show YWHAE Proteins) binding at canonical serum and glucocorticoid kinase 1 (SGK1 (show SGK1 Proteins)) phosphorylation sites.
Dlg3 (show DLG3 Proteins) exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 through its PPxY motifs. These interactions are required for Dlg3 (show DLG3 Proteins) monoubiquitination, apical membrane recruitment, and tight junction consolidation.
deficiency of Nedd4-2 in the renal tubules upregulated the Na(+)-Cl(-) cotransporter (show SLC12A3 Proteins)
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase NEDD4-like
, E3 ubiquitin-protein ligase NEDD4-like protein
, ubiquitin-protein ligase Rsp5
, neural precursor cell expressed, developmentally down-regulated 4
, neural precursor cell expressed, developmentally down-regulated gene 4b