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Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. Additionally we are shipping F-Box Protein 28 Antibodies (25) and F-Box Protein 28 Kits (15) and many more products for this protein.
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Refinement of the critical region of 1q41q42 microdeletion syndrome identifies FBXO28 as a candidate causative gene for intellectual disability and seizures.
Study identified F-box protein, FBXO28 that controls MYC (show MYC Proteins)-dependent transcription by non-proteolytic ubiquitylation. Depletion of FBXO28 or overexpression of an F-box mutant unable to support MYC (show MYC Proteins) ubiquitylation results in an impairment of MYC (show MYC Proteins)-driven transcription, transformation and tumourigenesis.
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box protein 28
, F-box only protein 28
, centromere protein 30