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F-Box Protein 32 Proteins (FBXO32)

FBXO32 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXO32 Antibodies (70) and FBXO32 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FBXO32 114907 Q969P5
FBXO32 67731 Q9CPU7
FBXO32 171043 Q91Z62
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Top FBXO32 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,951.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,968.17
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,968.17
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 9 to 11 Days
$229.85
Details

FBXO32 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus) ,

Top referenced FBXO32 Proteins

  1. Human FBXO32 Protein expressed in Wheat germ - ABIN1353808 : Lokireddy, McFarlane, Ge, Zhang, Sze, Sharma, Kambadur: Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting. in Molecular endocrinology (Baltimore, Md.) 2011 (PubMed)

More Proteins for F-Box Protein 32 (FBXO32) Interaction Partners

Zebrafish F-Box Protein 32 (FBXO32) interaction partners

  1. Atrogin-1 inactivation leads to progressive impairment of heart and skeletal muscle function and structure. Autophagy is severely impaired in Atrogin-1-deficient zebrafish embryos.

Rainbow Trout (Oncorhynchus mykiss) F-Box Protein 32 (FBXO32) interaction partners

  1. Results suggest that the up-regulation of FBXO32 is associated with skeletal and smooth muscle atrophy that occurs during fasting.

Human F-Box Protein 32 (FBXO32) interaction partners

  1. Our results indicate that abnormal SCF (show KITLG Proteins) activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of Dilated cardiomyopathy .

  2. Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system.

  3. Vitamin D3 might have an inhibitory effect on the expression of MAFbx and MuRF1 (show TRIM63 Proteins) in skeletal muscle.

  4. Atrogin-1 expression tended to be increased in the skeletal muscle of patients with malignant disease even before c (show TNF Proteins)ancer related cachexia weight loss.

  5. Expression of USP19 correlates with that of MuRF1 (show TRIM63 Proteins) and MAFbx/atrogin-1 in skeletal muscles

  6. FBXO32 targets Lys (show LYZ Proteins)-326 of c-Myc (show MYC Proteins) to form polyubiquitin (show UBB Proteins) chains, resulting in inhibition of cell proliferation.

  7. In conclusion, atrogin-1, MuRF1 (show TRIM63 Proteins), FOXO1 (show FOXO1 Proteins)/3A, and eIF3 (show EIF3A Proteins)-f mRNA, and protein levels, are differentially regulated by exercise contraction mode but not WPH supplementation combined with hypertrophy-inducing training.

  8. MAFbx not only regulates protein degradation, but also reduces protein synthesis, exerting a dual role in regulating cardiac mass and preventing from cardiac hypertrophy.

  9. FBXO32 methylation status and protein expression were independently associated with survival in ESCC. FBXO32 may be a functional tumor suppressor. Its inactivation through promoter methylation could play an important role in ESCC carcinogenesis.

  10. both MuRF1 (show TRIM63 Proteins) and MAFbx are enriched in skeletal, cardiac, and smooth muscle--REVIEW

Pig (Porcine) F-Box Protein 32 (FBXO32) interaction partners

  1. Porcine congenital splayleg (PCS) is a condition characterized by extensive fibre atrophy and raised fibre density. The combined differential expression of MAFbx and P311 (show C5orf13 Proteins) is of potential in the diagnosis of subclinical PCS.

Cow (Bovine) F-Box Protein 32 (FBXO32) interaction partners

  1. A study on the variability of bovine FBXO32 gene that is predictive of genetic potential for body length phenotype.

Mouse (Murine) F-Box Protein 32 (FBXO32) interaction partners

  1. Suggest role for atrogin-1 up-regulation in simvastatin-induced heart mitochondria dysfunction.

  2. Atrogin1 was upregulated in cancer cachexia mice. Atrogin1 knockdown protected skeletal muscle cells from TNF-alpha (show TNF Proteins) induced atrophy.

  3. Expression of USP19 correlates with that of MuRF1 (show TRIM63 Proteins) and MAFbx/atrogin-1 in skeletal muscles

  4. MAFbx not only regulates protein degradation, but also reduces protein synthesis, exerting a dual role in regulating cardiac mass and preventing from cardiac hypertrophy.

  5. mechanical vibration strongly down-regulates atrophy genes myostatin (show MSTN Proteins) and atrogin-1 both in vivo and in vitro.

  6. mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.

  7. atrogin-1 promotes cardiomyocyte health through mediating the interplay between the ubiquitin/proteasome system and autophagy/lysosome system and its alteration promotes development of cardiomyopathies

  8. Smad3 (show SMAD3 Proteins) expression is sufficient to stimulate atrogin-1 promoter activity, inhibit Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling and protein synthesis, and induce muscle fiber atrophy.

  9. Loss of SPARC (show SPARC Proteins) not only upregulates atrogin 1 expression but also enhances transforming growth factor (TGF)beta (show TGFB1 Proteins) signaling, which may in turn cause muscle atrophy.

  10. The muscle wasting effects of the myostatin (show MSTN Proteins)-atrogin-1 axis are not only limited to the degradation of MyoD (show MYOD1 Proteins) and eukaryotic translation initiation factor 3 subunit f (show EIF3F Proteins), but also encompass several other muscle proteins.

FBXO32 Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with F-Box Protein 32 Proteins (FBXO32)

  • F-box protein 32 (fbxo32)
  • F-box protein 32 (FBXO32)
  • F-box protein 32 (Fbxo32)
  • 4833442G10Rik protein
  • AI430017 protein
  • Atrogin1 protein
  • Fbx32 protein
  • Gm20361 protein
  • MAFbx protein
  • MGC56479 protein
  • zgc:56479 protein

Protein level used designations for F-Box Protein 32 Proteins (FBXO32)

F-box only protein 32 , atrogin-1 , F-box protein 32 , F-box only protein 32-like , atrogin 1 , muscle atrophy F-box protein , atrophy gene 1

GENE ID SPECIES
393891 Danio rerio
420343 Gallus gallus
464371 Pan troglodytes
475091 Canis lupus familiaris
704804 Macaca mulatta
100026040 Monodelphis domestica
100057506 Equus caballus
100142676 Ovis aries
100356177 Oryctolagus cuniculus
100387690 Callithrix jacchus
100462679 Salmo salar
100499214 Oncorhynchus mykiss
100580109 Nomascus leucogenys
114907 Homo sapiens
733657 Sus scrofa
513776 Bos taurus
67731 Mus musculus
171043 Rattus norvegicus
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