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FBXL4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXL4 Antibodies (32) and FBXL4 Proteins (4) and many more products for this protein.
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A clinical pattern of early-onset encephalopathy, persistent lactic acidosis, profound muscular hypotonia and typical facial dysmorphism should prompt initiation of molecular genetic analysis of FBXL4.
Mutations in FBXL4 are disease causing and establish FBXL4 as a mitochondrial protein (show COX6B2 ELISA Kits) with a possible role in maintaining mtDNA integrity and stability.
These data strongly support a role for FBXL4 in controlling bioenergetic homeostasis and mtDNA maintenance.
SKP1 (show SKP1 ELISA Kits)-Cul1 (show CUL1 ELISA Kits)-F-box and leucine-rich repeat protein 4 (SCF (show KITLG ELISA Kits)-FbxL4) ubiquitin ligase regulates lysine demethylase (show MBD2 ELISA Kits) 4A (KDM4A)/Jumonji domain-containing 2A (show KDM4A ELISA Kits) (JMJD2A (show KDM4A ELISA Kits)) protein
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 9 tandem leucine-rich repeats.
F-box and leucine-rich repeat protein 4
, F box and leucine-rich-repeat gene 4
, F-box/LRR-repeat protein 4-like
, f-box/LRR-repeat protein 4-like
, F-box/LRR-repeat protein 4