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anti-F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) Antibodies

FBXL5 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXL5 Kits (21) and FBXL5 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FBXL5 26234 Q9UKA1
FBXL5 242960 Q8C2S5
FBXL5 305424  
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Top anti-FBXL5 Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-FBXL5 Antibody Titration: 5.0ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of FBXL5 Antibody (N-term) (ABIN653358) in HepG2 cell line lysates (35 µg/lane). FBXL5 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of FBXL5 Antibody (N-term) (ABIN653358) in mouse heart tissue lysates (35 µg/lane). FBXL5 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Flow cytometric analysis of HepG2 cells using FBXL5 Antibody (N-term) Cat.-No AP51622PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry in formalin fixed and paraffin embedded testis tissue reacted with FBXL5 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-FBXL5 Antibody Titration: 0.2-1 ug/mlPositive Control: THP-1 cell lysate WB Suggested Anti-FBXL5  Antibody Titration: 0.2-1 µg/mL  Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated FACS, IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IHC, WB FBXL5 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Skeletal muscle cells (arrows) in Human Muscle. Magnification is at 400X FBXL5 antibody used at 5 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details

FBXL5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FBXL5 Antibodies

  1. Human Polyclonal FBXL5 Primary Antibody for FACS, IHC (p) - ABIN952279 : Salahudeen, Thompson, Ruiz, Ma, Kinch, Li, Grishin, Bruick: An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 6 references for ABIN952279

  2. Human Polyclonal FBXL5 Primary Antibody for FACS, IHC (p) - ABIN653358 : Vashisht, Zumbrennen, Huang, Powers, Durazo, Sun, Bhaskaran, Persson, Uhlen, Sangfelt, Spruck, Leibold, Wohlschlegel: Control of iron homeostasis by an iron-regulated ubiquitin ligase. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 4 references for ABIN653358

  3. Cow (Bovine) Polyclonal FBXL5 Primary Antibody for IHC, WB - ABIN2774689 : Ilyin, Rialland, Pigeon, Guguen-Guillouzo: cDNA cloning and expression analysis of new members of the mammalian F-box protein family. in Genomics 2000 (PubMed)

More Antibodies against FBXL5 Interaction Partners

Human F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) interaction partners

  1. FBXL5 regulates cortactin (show CTTN Antibodies) through induction of its ubiquitylation, and FBXL5 similarly regulates Snail1 (show SNAI1 Antibodies).

  2. FBXL5-mediated degradation of CITED2 (show CITED2 Antibodies) leads to the activation of HIF-1alpha (show HIF1A Antibodies).

  3. Data suggest a mechanism for the negative regulation of cortactin (show CTTN Antibodies) by FBXL5 protein in gastric cancer cells migration.

  4. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism

  5. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis

  6. Data indicate that F-box and leucine-rich repeat protein 5 (FBXL5)-Hr (hemerythrin-like domain) undergoes substantive structural changes when iron becomes limiting, accounting for its switch-like behavior.

  7. Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor.

  8. iron homeostasis is regulated by a proteolytic pathway that couples IRP2 (show IREB2 Antibodies) degradation to intracellular iron levels through the stability and activity of FBXL5

  9. observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 (show IREB2 Antibodies) regulation, and cellular responses to maintain mammalian iron homeostasis

  10. Our findings provide a potential mechanism by which p150(Glued (show DCTN1 Antibodies)) protein function is regulated by SCFs.

Mouse (Murine) F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) interaction partners

  1. we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS (show ROS1 Antibodies) biology.

  2. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis

  3. The FBXL5-IRP2 (show IREB2 Antibodies) axis is integral to control of iron metabolism in vivo.

FBXL5 Antigen Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus.

Gene names and symbols associated with FBXL5

  • F-box and leucine-rich repeat protein 5 (FBXL5) antibody
  • F-box and leucine-rich repeat protein 5 (fbxl5) antibody
  • F-box and leucine-rich repeat protein 5 (LOC100351566) antibody
  • F-box and leucine-rich repeat protein 5 (Fbxl5) antibody
  • Fbl4 antibody
  • FBL5 antibody
  • FBXL5 antibody
  • Fir4 antibody
  • FLR1 antibody
  • MGC53238 antibody
  • wu:fb52d06 antibody

Protein level used designations for FBXL5

F-box and leucine-rich repeat protein 5 , F-box/LRR-repeat protein 5 , F-box/LRR-repeat protein 5-like , F-box protein FBL4/FBL5 , F-box protein FBL5 , p45SKP2-like protein

GENE ID SPECIES
479085 Canis lupus familiaris
100511143 Sus scrofa
422829 Gallus gallus
380440 Xenopus laevis
432131 Xenopus laevis
461125 Pan troglodytes
496483 Xenopus (Silurana) tropicalis
100012405 Monodelphis domestica
100074228 Ornithorhynchus anatinus
100173556 Pongo abelii
100351566 Oryctolagus cuniculus
100388303 Callithrix jacchus
100605502 Nomascus leucogenys
26234 Homo sapiens
519695 Bos taurus
242960 Mus musculus
305424 Rattus norvegicus
322181 Danio rerio
101106171 Ovis aries
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