FBXL5 antibody (AA 31-130)

Catalog No. ABIN1385651

The Rabbit Polyclonal anti-FBXL5 antibody is suitable to detect FBXL5 in samples from Human. It has been validated for FACS, IHC (p), IHC (fro), IF and ICC.

Quick Overview for FBXL5 antibody (AA 31-130) (ABIN1385651)

Target: FBXL5 (F-Box and Leucine-Rich Repeat Protein 5 (FBXL5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL5 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-FBXL5 Antibody

Binding Specificity: AA 31-130

Purpose: FBXL5 Polyclonal Antibody

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FBXL5

Isotype: IgG

Application Details

Application Notes: IHC-P(IHC-P=1:100-500), IHC-F(IHC-F=1:100-500), IF(IF=1:50-200), Flow-Cyt(Flow-Cyt=1 μg/Test), ICC/IF(ICC/IF=1:25)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FBXL5

Target: FBXL5 (F-Box and Leucine-Rich Repeat Protein 5 (FBXL5))

Alternative Name: FBXL5

Background:

Synonyms: F box and leucine rich repeat protein 5, F box/LRR repeat protein 5, F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, F-box/LRR-repeat protein 5, FBL4, FBL5, FBXL5, FBXL5_HUMAN, FLR1, p45SKP2 like protein, p45SKP2-like protein.

Background: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

Gene ID: 26234

Pathways: Transition Metal Ion Homeostasis