FBXL5 antibody (Middle Region)

Catalog No. ABIN2774689

Product Details anti-FBXL5 Antibody

Target: FBXL5 (F-Box and Leucine-Rich Repeat Protein 5 (FBXL5))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: VHWARGDWYS GPATELDTEP DDEWVKNRKD ESRAFHEWDE DADIDESEES

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against FBXL5. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FBXL5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 691 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXL5

Target: FBXL5 (F-Box and Leucine-Rich Repeat Protein 5 (FBXL5))

Alternative Name: FBXL5 (FBXL5 Products)

Synonyms: fbxl5 antibody, MGC53238 antibody, FBXL5 antibody, FBL4 antibody, FBL5 antibody, FLR1 antibody, Fbl4 antibody, Fir4 antibody, wu:fb52d06 antibody, F-box and leucine rich repeat protein 5 antibody, F-box and leucine-rich repeat protein 5 S homeolog antibody, F-box and leucine-rich repeat protein 5 L homeolog antibody, F-box and leucine-rich repeat protein 5 antibody, FBXL5 antibody, fbxl5.S antibody, fbxl5.L antibody, fbxl5 antibody, Fbxl5 antibody

Background: FBXL5 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXL5 belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.
Alias Symbols: FBL4, FBL5, FLR1
Protein Interaction Partner: NABP2, CUL1, SNAI1, SKP1, FBXL5, HERC2, UBC, IREB2, ACO1, RBX1, MUS81, MMS19, FAM96B, ORC4, EP300, SMURF1, BTG1, COPS5, PLK1, CSNK2B, DCTN1,
Protein Size: 691

Molecular Weight: 76 kDa

Gene ID: 26234

NCBI Accession: NM_012161, NP_036293

UniProt: Q9UKA1

Pathways: Transition Metal Ion Homeostasis