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Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. Additionally we are shipping F-Box Protein 15 Kits (12) and F-Box Protein 15 Proteins (5) and many more products for this protein.
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These data suggest that FBXO15 and Ube2r1 regulate P-gp expression through the ubiquitin-proteasome pathway.
TDH, responsible for mitochondrial production of acetyl-CoA (show LPCAT1 Antibodies) in mouse embryonic stem cells, and the acetyltransferase GCN5L1 (show BLOC1S1 Antibodies) cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein (show FBXO30 Antibodies) transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
Fbxo15 mediates degradation of cardiolipin synthase1 in pneumonia.
Fbx15 is a novel target of Oct3/4 (show POU5F1 Antibodies) but is dispensable for embryonic stem cell self-renewal, development, and fertility.
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box protein 15
, F-box only protein 15
, f-box only protein 15-like