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FANCE encodes the complementation group E subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2. Additionally we are shipping Fanconi Anemia, Complementation Group E Proteins (2) and many more products for this protein.
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Cow (Bovine) Polyclonal FANCE Primary Antibody for WB - ABIN2786176
Wang, Kennedy, Ray, Stuckert, Ellenberger, DAndrea: Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. in Molecular and cellular biology 2007
Human Polyclonal FANCE Primary Antibody for ELISA, IHC - ABIN4310515
Barroso, Pita, Arias, Menendez, Zamora, Blanco, Benitez, Ribas: The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. in Breast cancer research and treatment 2009
A novel alternative splicing event of the FANCE gene has been characterized. FANCEDelta4 cannot support the activation of the FANC-BRCA pathway and DNA repair.
a phenylalanine located at the highly conserved extreme C terminus, referred to as Phe-522, is a critical residue for mediating the monoubiquitination of the FANCD2 (show FANCD2 Antibodies)-FANCI (show FANCI Antibodies) complex.
FANCE protein is part of the FA nuclear complex, binding FANCC & FAN (show PALB2 Antibodies)CD2. It is required for the nuclear accumulation of FANCC and provides a bridge between the FA complex and FANCD2. FANCC mutants do not bind FANCE or prevent chromosome breakage.
This Fanconi anemia protein (show FANCF Antibodies) promotes the nuclear accumulation of FANCC (show FANCC Antibodies).
FANCC (show FANCC Antibodies), FANCE, and FANCD2 (show FANCD2 Antibodies) form a ternary complex in the Fanconi anemia (show PALB2 Antibodies) DNA damage response pathway
nuclear accumulation of FANCE does not rely solely on its nuclear localization signal motifs, but also on FANCC (show FANCC Antibodies)
Chk1 (show CHEK1 Antibodies)-mediated phosphorylation of FANCE is required for a function independent of FANCD2 (show FANCD2 Antibodies) monoubiquitination.
Disease-associated mutations disrupt the FANCE-FANCD2 (show FANCD2 Antibodies) interaction, providing structural insight into the molecular mechanisms of Fanconi Anaemia pathogenesis.
Primary ovarian insufficiency is induced by Fance mutation in a mouse model.
The fact that defects in the human ortholog result in Fanconi anemia (show PALB2 Antibodies) disease suggests that this protein has a critical function and is likely evolutionarily conserved.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E.
Fanconi anemia, complementation group E
, Fanconi anemia E
, Fanconi anemia group E protein
, fanconi anemia group E protein-like
, Fanconi anemia group E protein-like