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FSCN2 encodes a member of the fascin protein family. Additionally we are shipping FSCN2 Antibodies (39) and FSCN2 Proteins (9) and many more products for this protein.
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A quantitative trait locus on chromosome 5 modifies hearing loss associated with the fascin-2 variant of DBA (show RPS19 ELISA Kits)/2J mice.
Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles.
The results of this study demonistrated that fascin-2 crosslinks function to slow actin depolymerization at stereocilia tips to maintain stereocilia length.
Mutation in the Fscn2 gene underlies the early onset progressive hearing loss of DBA (show RPS19 ELISA Kits)/2J mice attributed to the ahl8 locus.
Tax-mediated transcriptional induction of Fascin requires NF-kappaB- and TRR-dependent promoter activation, and a promoter-independent, but PP2-sensitive signaling pathway.
the serum fascin (show FSCN1 ELISA Kits) level is an effective indicator of tumor aggressiveness, and that it plays an important role in the prognosis of NSCLC, particularly for non-distant metastatic patients.
Data indicate the specific contribution of fascin (show FSCN1 ELISA Kits) and cortactin (show CTTN ELISA Kits) during invadopodium formation.
The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin (show FSCN1 ELISA Kits)
Fascin (show FSCN1 ELISA Kits) expression predicts survival after potentially curative resection of node-positive colon cancer.
The 208delG mutation in the FSCN2 gene produces not only autosomal dominant retinitis pigmentosa but also ADMD (autosomal dominant macular degeneration)
The photoreceptor-specific FSCN2 gene showed a relatively high number of sequence variations.
The 208delG mutation in FSCN2 is not associated with hereditary retinal degeneration in the Chinese individuals examined.
In ovarian tumors fascin (show FSCN1 ELISA Kits) is associated with certain features of increased tumor aggressiveness.
Higher fascin (show FSCN1 ELISA Kits) scores correlated positively with tumor differentiation of esophageal SqCC. Significantly worse prognosis in patients with high scores of fascin (show FSCN1 ELISA Kits), poor differentiation, T4 stage, positive for lymph node metastasis and distant metastasis
This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.
, putative fascin 1
, retinal fascin
, fascin 2, retinal