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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Proteins (11) and FTO Kits (7) and many more products for this protein.
Showing 10 out of 145 products:
Human Polyclonal FTO Primary Antibody for EIA, IHC (p) - ABIN499863
Scuteri, Sanna, Chen, Uda, Albai, Strait, Najjar, Nagaraja, Orrú, Usala, Dei, Lai, Maschio, Busonero, Mulas, Ehret, Fink, Weder, Cooper, Galan, Chakravarti, Schlessinger, Cao, Lakatta, Abecasis: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. in PLoS genetics 2008
Human Polyclonal FTO Primary Antibody for ELISA, WB - ABIN316349
Gerken, Girard, Tung, Webby, Saudek, Hewitson, Yeo, McDonough, Cunliffe, McNeill, Galvanovskis, Rorsman, Robins, Prieur, Coll, Ma, Jovanovic, Farooqi, Sedgwick, Barroso, Lindahl, Ponting, Ashcroft et al.: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. ... in Science (New York, N.Y.) 2007
Human Polyclonal FTO Primary Antibody for EIA, WB - ABIN453035
Scott, Mohlke, Bonnycastle, Willer, Li, Duren, Erdos, Stringham, Chines, Jackson, Prokunina-Olsson, Ding, Swift, Narisu, Hu, Pruim, Xiao, Li, Conneely, Riebow, Sprau, Tong, White, Hetrick, Barnhart, Bark, Goldstein, Watkins, Xiang, Saramies, Buchanan, Wat: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. in Science (New York, N.Y.) 2007
Cow (Bovine) Monoclonal FTO Primary Antibody for IF, IHC (p) - ABIN782440
Fredriksson, Hägglund, Olszewski, Stephansson, Jacobsson, Olszewska, Levine, Lindblom, Schiöth: The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. in Endocrinology 2008
carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions.
An SNP in the FTO (rs9939609) gene but not in the MC4R (show MC4R Antibodies) (rs17782313) gene was significantly associated with prepregnancy body mass index (BMI) >/=25 kg/m(2) (relative riskFTO = 2.1; 95% confidence interval [CI], 1.4-3.1). SNPs were not statistically associated with excessive gestational weight gain (GWG) or postpartum weight retention (PPWR).
genetic association studies in population in Spain: Data suggest that an SNP in FTO (rs9939609) is associated with insulin (show INS Antibodies) resistance (IR) and hyperlipidemia; in the population studied, maternal FTO polymorphism affects in an opposite manner than neonatal FTO the IR and cardiovascular disease markers in term, normo-weight, appropriate-for-gestational-age neonates.
Our findings demonstrate that ENPP1 (show ENPP1 Antibodies), TCF7L2 (show TCF7L2 Antibodies), and FTO may predispose to T2DM in the mixed-ancestry population.
FTO rs9939609, MC4R (show MC4R Antibodies) rs17782313, and PPARgamma (show PPARG Antibodies) rs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men.
Mothers' FTO rs9939609 and LEPR rs1137101 gene polymorphisms presented an impact on birth weight and newborns' BMI, therefore being involved in the newborns' nutritional status and in the design of a potential protocol.
The FTO gene in Turkish adults contributes independently to obesity in women and-by interacting with BMI-to MetS (show ETV3 Antibodies) and insulin (show INS Antibodies) resistance in men.
This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians.
Our study suggests that FTO exerts its effect on BMI, at least partly, through energy expenditure mechanisms such as TSS (show RPL38 Antibodies). Further research into the intersection of genetics, sedentary behavior and obesity-related outcomes is warranted.
results show no difference in allele frequencies between bipolar cases and controls and we conclude that there is no evidence that FTO variants affect susceptibility to affective disorder
Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.
Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma (show PPARG Antibodies) and PI3K/Akt (show AKT1 Antibodies) signaling.
These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4 (show ANGPTL4 Antibodies).
FTO-dependent N6-methyladenosine demethylation may be affected by betaine.
FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1 (show ARNTL Antibodies)-induced transcription.
FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.
FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2 (show CSE1L Antibodies).
FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.
data suggest that IRX3 (show IRX3 Antibodies) is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition
FTO silencing did not modify PPARgamma2 (show PPARG Antibodies) mRNA levels. Partial reduction of FTO did not influence the first step of 3T3-L1 adipocyte differentiation.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Antibodies) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
, protein fto
, protein fatso
, fat mass and obesity associated protein
, Protein fatso