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Fc Fragment of IgG, Receptor, Transporter, alpha Proteins (FCGRT)

FCGRT encodes a receptor that binds the Fc region of monomeric immunoglobulin G. Additionally we are shipping FCGRT Antibodies (74) and FCGRT Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FCGRT 2217 P55899
FCGRT 29558 P13599
FCGRT 14132 Q61559
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Top FCGRT Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Cynomolgus His tag,Strep Tag 50 μg Log in to see 2 to 3 Days
$346.50
Details
HOST_HEK-293 Cells Rat His tag,Strep Tag 50 μg Log in to see 2 to 3 Days
$346.50
Details
HOST_HEK-293 Cells Human His tag,Strep Tag 50 μg Log in to see 2 to 3 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Macaca fascicularis His tag Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) (AA 24-297) protein (His tag) expressed in mammalien cells 1 mg Log in to see 56 to 66 Days
$2,715.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,722.50
Details

FCGRT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
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Rat (Rattus) ,
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Mouse (Murine) , ,
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Top referenced FCGRT Proteins

  1. Cynomolgus FCGRT Protein expressed in HEK-293 Cells - ABIN2181081 : Goebl, Babbey, Datta-Mannan, Witcher, Wroblewski, Dunn: Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells. in Molecular biology of the cell 2008 (PubMed)
    Show all 2 references for ABIN2181081

  2. Human FCGRT Protein expressed in HEK-293 Cells - ABIN2181085 : Gorevic, Munoz, Casey, DiRaimondo, Stone, Prelli, Rodrigues, Poulik, Frangione: Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis. in Proceedings of the National Academy of Sciences of the United States of America 1986 (PubMed)
    Show all 2 references for ABIN2181085

  3. Human FCGRT Protein expressed in Wheat germ - ABIN1353903 : Deissler, Lang, Lang: Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor. in Experimental eye research 2015 (PubMed)

More Proteins for Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) Interaction Partners

Human Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) interaction partners

  1. Data indicate improved pharmacokinetics through enhanced neonatal Fc receptor (FcRn) interactions were apparent for a complementarity-determining region (CDR (show RUNX1T1 Proteins)) charge-patch normalized monoclonal antibody (mAb) which was affected by non-specific clearance.

  2. analysis of binding motifs in the hFCGRT promoter that interact with their corresponding (Sp1 (show PSG1 Proteins), Sp2, Sp3, c-Fos, c-Jun (show JUN Proteins), YY1 (show YY1 Proteins), and C/EBPbeta (show CEBPB Proteins) or C/EBPdelta (show CEBPD Proteins)) transcription factors (TFs) suggests their involvement in regulation of human FCGRT gene expression

  3. These data indicate that human FcRn facilitates the transepithelial transport of IgE in the form of IgG anti-IgE/IgE ICs.

  4. none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A (show CD16 Proteins) F158V and FCGR2B (show FCGR2B Proteins) I232T nsSNPs and the VNTR in FCGRT, showed an association with the response to TNFi in patients with rheumatoid arthritis

  5. Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris (show DSG3 Proteins).

  6. FcRn binding activity of a large set of Fc-fusion samples after thermal stress, was investigated.

  7. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.

  8. Molecular dynamic simulations of human FcRn-Fc binding structures proposed that the protein-protein binding interface is composed of three subsites.

  9. This mAb panel provides a powerful resource for probing the biology of human FcRn and for the evaluation of therapeutic FcRn blockade strategies.

  10. domain I and III of albumin (show ALB Proteins) required for optimal pH-dependent binding to the neonatal Fc receptor

Cow (Bovine) Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) interaction partners

  1. The transport of IgGs in the mammary gland, by FcRn, was investigated.

  2. The present data support the notion that FcRn might be involved in the transfer of maternal immunoglobulins and in the local defense mechanism of the mammary gland.

  3. FcRn alpha chain gene has acquired several repetitive sequences in its 5'-flanking region, including multiple SINE and LINE elements. Potential binding sites for transcription factors within the 5'-flanking sequence were identified

  4. haplotype could also weaken the IgG-FcRn affinity, which may increase the IgG concentration in the milk.

Mouse (Murine) Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) interaction partners

  1. Preproinsulin (show INS Proteins) fused to Fc administered to pregnant mice efficiently accumulated in fetuses through the placental neonatal Fc receptor and protected them from subsequent diabetes development.

  2. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.

  3. Characterization and screening of IgG binding to the neonatal Fc receptor.

  4. Fc receptor promotes formation of subepithelial immune complexes and subsequent glomerular pathology leading to proteinuria

  5. Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.

  6. Extending serum half-life of albumin (show ALB Proteins) by engineering neonatal Fc receptor (FcRn) binding.

  7. FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance

  8. Neonatal Fc receptor for IgG uptake mediates intestinal absorption of IgG(1) anti-IgE/IgE immune complexes.

  9. Nck (show NCK1 Proteins) and Cdc42 (show CDC42 Proteins) co-operate to recruit N-WASP (show WASL Proteins) to promote FcgammaR-mediated phagocytosis.

  10. AMG (show AMELX Proteins) 386 clearance in FcRn-knockout mice was 18-fold faster at the 3-mg/kg dose.

FCGRT Protein Profile

Protein Summary

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FCGRT

  • Fc fragment of IgG, receptor, transporter, alpha (FCGRT)
  • Fc fragment of IgG, receptor, transporter, alpha (Fcgrt)
  • Fc receptor, IgG, alpha chain transporter (Fcgrt)
  • alpha-chain protein
  • FcRn protein

Protein level used designations for FCGRT

FcRn alpha chain , IgG Fc fragment receptor transporter alpha chain , IgG receptor FcRn large subunit p51 , immunoglobulin receptor, intestinal, heavy chain , major histocompatibility complex class I-like Fc receptor , neonatal Fc receptor , neonatal Fc-receptor for Ig , IgG transcytosis and recycling receptor , MHC class I-related Fc gamma receptor , igG receptor FcRn large subunit p51 , neonatal Fc receptor FcRn , Fc receptor , Fc fragment immunoglobulin G receptor , Fc receptor, IgG, alpha chain transporter , igG Fc fragment receptor transporter alpha chain

GENE ID SPECIES
2217 Homo sapiens
476414 Canis lupus familiaris
397399 Sus scrofa
338062 Bos taurus
29558 Rattus norvegicus
14132 Mus musculus
Selected quality suppliers for FCGRT Proteins (FCGRT)
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