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Fermitin Family Member 1 Proteins (FERMT1)

FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. Additionally we are shipping FERMT1 Antibodies (48) and FERMT1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FERMT1 241639 P59113
FERMT1 55612 Q9BQL6
Rat FERMT1 FERMT1 296179  
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Top FERMT1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FERMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Fermitin Family Member 1 (FERMT1) Interaction Partners

Zebrafish Fermitin Family Member 1 (FERMT1) interaction partners

  1. The rof/kindlin-1 mutant zebrafish provi (show ILK Proteins)des a unique model system to study epidermal adhesion mechanisms in vivo.

Mouse (Murine) Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was als (show FERMT2 Proteins)o found highly expressed in endoderm/ectoderm-derived tissues in embryos.

  2. Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta (show TGFB1 Proteins) activation and Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) signal inhibition.

  3. Kindlin-1 and Kindlin-2 (show FERMT2 Proteins) have opposite roles in lung cancers

  4. Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.

  5. Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

Human Fermitin Family Member 1 (FERMT1) interaction partners

  1. we show that a certain number of KS patients may harbor FERMT1 transcriptional regulatory mutations which are not routinely detected.

  2. Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 (show FERMT2 Proteins) is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.

  3. FERMT1 mutation causing Kindler syndrome.

  4. our data suggest that Kindlin-1 could play an important role in hepatocellular carcinoma and might serve as a promising prognostic marker and potential target for hepatocellular carcinoma therapy.

  5. A spectrum of FERMT1 mutations in 13 Iranian families with a diagnosis of Kindler syndrome have been ascertained.

  6. We identified a novel mutation in FERMT1. These data are in agreement with the fact that the majority of KS-causing mutations in FERMT1 lead to premature termination of translation and to loss of kindlin-1 function in Kindler sysndrome

  7. C-terminal LIM (show PDLIM5 Proteins) domains of migfilin (show FBLIM1 Proteins) dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin (show FBLIM1 Proteins) dynamics.

  8. Data uncover a role for kindlin-1 in the regulation of integrin trafficking and adhesion turnover.

  9. Short interfering RNA-mediated depletion of Kindlin-1 increases formation of abnormal mitotic spindles which is dependent on the ability of Kindlin-1 to bind integrins and Polo-like kinase 1-mediated Kindlin-1 phosphorylation.

  10. Individuals with Kindler syndrome (KS) have loss-of-function mutations in the FERMT1 gene

Xenopus laevis Fermitin Family Member 1 (FERMT1) interaction partners

  1. Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut (show GUSB Proteins) and eventual lethality by tadpole stages.

FERMT1 Protein Profile

Protein Summary

This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.

Gene names and symbols associated with FERMT1

  • fermitin family member 1 (FERMT1)
  • tRNA methyltransferase 6 homolog (S. cerevisiae) (trmt6)
  • fermitin family member 1 (fermt1)
  • fermitin family homolog 1 (Drosophila) (Fermt1)
  • fermitin family member 1 (Fermt1)
  • 5830467P10Rik protein
  • C20orf42 protein
  • DTGCU2 protein
  • KIND1 protein
  • Kindlin-1 protein
  • RGD1306816 protein
  • si:ch73-22c10.1 protein
  • UNC112A protein
  • URP1 protein
  • wu:fc32b07 protein
  • zgc:123193 protein

Protein level used designations for FERMT1

fermitin family member 1 , fermitin family homolog 1 , fermitin family homolog 1-like , unc-112-related protein 1 , UNC112 related protein 1 , kindlerin , kindlin 1 , kindlin syndrome protein , UNC-112 related protein 1 , fc32b07

GENE ID SPECIES
458088 Pan troglodytes
563475 Danio rerio
718297 Macaca mulatta
100407542 Callithrix jacchus
416727 Gallus gallus
100466357 Ailuropoda melanoleuca
100492800 Xenopus (Silurana) tropicalis
100548276 Meleagris gallopavo
241639 Mus musculus
524427 Bos taurus
55612 Homo sapiens
296179 Rattus norvegicus
100332544 Danio rerio
379119 Xenopus laevis
485775 Canis lupus familiaris
100051761 Equus caballus
100157961 Sus scrofa
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