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The protein encoded by FRS3 is a substrate for the fibroblast growth factor receptor. Additionally we are shipping Fibroblast Growth Factor Receptor Substrate 3 Antibodies (44) and Fibroblast Growth Factor Receptor Substrate 3 Kits (9) and many more products for this protein.
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signaling via Pax6 expression through Shp2-binding sites of XFrs3 is necessary for the eye development in Xenopus laevis
Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR (show EGFR Proteins) family members and suggest a role for FRS2beta as a tumor suppressor.
an FRS2beta-CIN85 (show SH3KBP1 Proteins)/CD2AP (show Cd2ap Proteins)-Cbl (show CBL Proteins) axis for downregulation of ErbB2 (show ERBB2 Proteins) may regulate ErbB2 (show ERBB2 Proteins) protein levels in physiological and pathological settings
FRS2 (show FRS2 Proteins) PTB (show PTBP1 Proteins) domain conformation regulates interactions with divergent neurotrophic receptors
FRS2beta can compensate for the loss of FRS2alpha (show FRS2 Proteins) for activation of MAP kinase (show MAPK1 Proteins) when expressed in fibroblasts
SNT-2 (show SNTB1 Proteins) negatively regulates ERK2 (show MAPK1 Proteins) signaling activated via EGF (show EGF Proteins) stimulation through direct binding to ERK2 (show MAPK1 Proteins)
Novel mechanism of negative control of EGFR (show EGFR Proteins) tyrosine kinase (show TXK Proteins) activity with SNT-2 (show SNTB1 Proteins) by recruiting ERK2 (show MAPK1 Proteins).
Analysis of a mutant Fgfr1 (show FGFR1 Proteins) allele, unable to bind to the adaptor protein, Frs2 (show FRS2 Proteins)/3, indicates that Sox2 (show SOX2 Proteins) maintenance can be
data indicate that the fibroblast growth factor receptor substrate 2 (show FRS2 Proteins) and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK (show NTRK1 Proteins) oncogenes
Some essential functions of Fgfr1 are mediated by Frs-independent signaling.
ULK2 (show ULK2 Proteins), by interaction with FRS2 (show FRS2 Proteins)/3 and inhibition of SynGAP (show SYNGAP1 Proteins), functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1 (show FGFR1 Proteins).
SNT family proteins may play significant roles in cellular transformation triggered by NPM-ALK.
The results showed that the interaction of full-length FRS2beta with FGFR1 (show FGFR1 Proteins) was not enhanced by activation of the receptor kinase.
Prominent expression of Frs2beta protein in neural cells and its association with intracellular vesicles is reported.
The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.
fibroblast growth factor receptor substrate 3
, FGFR substrate 3
, FGFR-signaling adaptor SNT2
, suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)
, suc1-associated neurotrophic factor target 2