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FN1 encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Additionally we are shipping Fibronectin Kits (53) and Fibronectin Proteins (23) and many more products for this protein.
Showing 10 out of 213 products:
Human Monoclonal Fibronectin Primary Antibody for IHC, WB - ABIN108418
Vesaluoma M,Mertaniemi P,Mannonen S,Lehto I,Uusitalo R,Sarna S,Tarkkanen A,Tervo T: Cellular and plasma fibronectin in the aqueous humour of primary open-angle glaucoma, exfoliative glaucoma and cataract patients. in Eye 1998
Show all 5 references for ABIN108418
Human Monoclonal Fibronectin Primary Antibody for FACS, IHC - ABIN969149
Ryschich, Khamidjanov, Kerkadze, Büchler, Zöller, Schmidt: Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer. in Pancreas 2009
Show all 2 references for ABIN969149
Human Monoclonal Fibronectin Primary Antibody for FACS, ELISA - ABIN969520
Huang, Zhang, Kim, Ge, Annis, Mosher, Greenspan: Fibronectin binds and enhances the activity of bone morphogenetic protein 1. in The Journal of biological chemistry 2009
Show all 2 references for ABIN969520
Human Polyclonal Fibronectin Primary Antibody for ICC, IHC (fro) - ABIN1077665
Zheng, Hu, Huang, Xu, Yang, Li: In vivo bioengineered ovarian tumors based on collagen, matrigel, alginate and agarose hydrogels: a comparative study. in Biomedical materials (Bristol, England) 2015
Human Polyclonal Fibronectin Primary Antibody for WB - ABIN2776846
Ramani, Haun: The extracellular matrix protein fibronectin is a substrate for kallikrein 7. in Biochemical and biophysical research communications 2008
Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.
Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage
Fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
reduction of fn1 function enables rescue of cardiac fusion in hand2 (show HAND2 Antibodies) mutants
Fibronectin regulates epithelial organization during myocardial migration in zebrafish.
EDA (show EDA Antibodies)-FN concentration was significantly higher and the molecular FN-fibrin complexes of 1000 kDa and higher occurred more often in the plasma of the patients' group with high risk of coronary artery disease
FN and HtrA1 (show HTRA1 Antibodies) are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation
fibronectin as a potential indicator of an extracellular matrix remodeling related to the hypertrophic cardiomyopathy
Overexpression of FN1 is associated with lung cancer.
Missense variant in FN1 gene is associated with familial hematuria.
HMGA2 promoted colorectal cancer metastasis and epithelial-mesenchymal transition via activation of the FN1 and IL11 (show IL11 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathways.
Urolithin A incubation caused the up-regulation of CDKN1A and down-regulation of FN-1 in prostate cancer cells.
Crosslinker-mediated immobilization showed significant fibronectin grafting on surfaces, which provided K562 cell adhesion and growth advantage. siRNA nanoparticle silencing was similarly effective on fibronectin -adhered and suspension-growing K562 cells
Data suggest fetal fibronectin is up-regulated in vaginal secretions of women with signs of preterm labor (24-34 weeks) who deliver before term (that is, result in premature birth) compared to those who deliver at term; this finding holds for blind vaginal swabs collected without aid of speculum or routine cervicovaginal swabs; study was conducted at large maternity hospital in Egypt.
Pharmacophore-based screening targeted at upregulated FN1, MMP-9 (show MMP9 Antibodies), APP (show APP Antibodies) reveals therapeutic compounds for nasopharyngeal carcinoma.
The results very comprehensively demonstrate distinct signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 (show LGALS3 Antibodies) as opposed to fibronectin.
Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
These results suggest that the Rac1 regulation of the FN arrangement is involved in retinoic acid-induced cleft palate.
Fibrillar cellular fibronectin supports platelet adhesion, activation, aggregation and procoagulant activity via the interplay of a series of receptors i.e. integrins alpha5beta1 and alphaIIbbeta3, the GPIb-V-IX complex, GPVI (show GP6 Antibodies) and Toll-like receptor 4 (show TLR4 Antibodies).
Fn1 synthesized by the neural crest mediated morphogenesis of the aortic arch artery and differentiation of neural crest cells into vascular smooth muscle cells by regulating Notch (show NOTCH1 Antibodies) signaling.
A novel mechanism of transcriptional regulation of fibronectin through CREB (show CREB1 Antibodies).
Hypercholesterolemic mice deficient in extra domain A of fibronectin exhibit reduced cerebral thrombosis.
the epithelial interaction between fibronectin and beta1 integrin is important for ameloblast differentiation and enamel formation.
An (as yet unknown) integrin alpha5-dependent signal extrinsic to the pharyngeal endothelium mediates the formation of the 4th pharyngeal arch arteries through fibronectin.
TLR4 (show TLR4 Antibodies) signaling contributes to EDA (show EDA Antibodies)(+)-FN-mediated exacerbation of atherosclerosis.
plasma FN assembly into bone matrix in vitro requires FXIIIA transglutaminase activity making pFN assembly an active, osteoblast-mediated process.
Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta (show TGFB1 Antibodies) when cultured in the presence of fibronectin and unpolymerized or polymerized collagen.
Putative function of fibronectin and its receptor (integrin alpha(5 (show ITGA5 Antibodies))beta(1)) in male and female gametes during bovine fertilization in vitro.
These results highlight a crucial role for caveolin-1 (show CAV1 Antibodies) in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins.
P. multocida-Fn interaction may play a role in the bacterium adherence to host cells, and this may be mediated by bacterial surface proteins with preferential affinity for the Hep-1 binding domain of Fn
The expression of extracellular matrix molecules fibronectin and osteopontin (show SPP1 Antibodies) in vitreous and retina samples in autoimmune uveitis was investigated.
The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process.
The relationship between hyaluronan synthesis and levels of versican (show Vcan Antibodies), fibronectin and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.
fibronectin has a cryptic binding site for tenascin (show TNC Antibodies)
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
, gene C
, cold-insoluble globulin
, migration-stimulating factor
, cumulus cell-specific fibronectin 1 transcript
, embryo-specific fibronectin 1 transcript
, fibronectin ED-A- region
, fibronectin variable region