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A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. Additionally we are shipping Fibulin 4 Antibodies (95) and Fibulin 4 Kits (10) and many more products for this protein.
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Findings suggested that fibulin-4 is important for the proteolytic activation of lysyl oxidase (show LOX Proteins) which has a pivotal role in cross-linking of collagen and elastin (show ELN Proteins).
Data indicates that Fibulin-4 is a novel gene that is found overexpressed in ovarian cancer and associated with poor prognostic clinicopathologic features.
pulmonary emphysema in aneurysmal Fibulin-4 deficient (Fibulin-4(R)) mice
Homozygous mutations in exon 7 of the FBLN4 gene can produce lethal vasculopathy.
This study demonstrated that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with cervical carcinoma.
The expression level of EFEMP2 is dramatically increased in colorectal cancer patients, even at the early stage, compared with healthy controls.
Studied Fibulin-4 expression in aortic wall to find out its role in aortic dissection development. Used samples of aortic wall from 10 patients operated for acute ascending aortic dissection and five patients for chronic ascending aortic dissection.
Data indicate mutations of FBLN4, FBLN5, and LTBP4 in 12 probands presenting with type 1 recessive cutis laxa.
A lethal, genetic disorder characterized by severe deformation of elastic arteries, was linked to novel mutations in the FBLN4 gene.
Low EFEMP2 expression is associated with malignant pleural mesothelioma.
These data provide new insights in the molecular interaction between Fibulin-4 and TGF-beta (show TGFB1 Proteins) pathway regulation in the pathogenesis of aortic aneurysms.
Fibulin-4 serves as a potential scaffolding protein during collagen maturation in the extracellular space and loss of fibulin-4 disrupts collagen synthesis and maturation.
fibulin-4 plays a role in regulating collagen fibril assembly and offer a preclinical platform for developing treatments for autosomal recessive cutis laxa 1B.
MBP1 (show ENO1 Proteins) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (show ENO1 Proteins) to reduce Ab pathology and improve behavioral performance.
Smooth muscle cell (SMC (show DYM Proteins))-specific deletion of Fibulin-4 knockout ascending aorta and carotid artery showed mechanical changes in the axial direction.
Compared to control SMCs, the modulus of Eln (show ELN Proteins)-/- SMCs is reduced by 40%, but is unchanged in Fbln4-/- SMCs. The Eln (show ELN Proteins)-/- SMC (show DYM Proteins) modulus is rescued by soluble or alpha elastin (show ELN Proteins) treatment.
abnormal up-regulation of angiotensin-converting enzyme (ACE (show ACE Proteins)) in SMCs and subsequent activation of angiotensin II (AngII) signaling are involved in the onset of aortic aneurysms in Fbln4 mice.
Data show that fibulin-4 staining intensity in the ligamentum flavum was greatest at P14, though moderately strong at P7 and P21, and efore P7 and after P28, staining was detectable but relatively minimal.
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene.
, EGF-containing fibulin-like extracellular matrix protein 2
, mutant p53 binding protein 1
, EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2)
, mutant p53-binding protein 1
, Protein H411