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The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. Additionally we are shipping Follicle Stimulating Hormone, beta Polypeptide Proteins (28) and Follicle Stimulating Hormone, beta Polypeptide Kits (10) and many more products for this protein.
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FSH (show BRD2 Antibodies)-deficient zebrafish (fshb(-/-)) were surprisingly fertile in both sexes; however, the development of both the ovary and testis was significantly delayed.
zfFSHbeta promoter responded to 6h of gonadotropin-releasing hormone treatment by activating calcium influx and protein kinase C (PKC (show PKC Antibodies)), but after 24h, GnRH (show GNRH1 Antibodies) induction was generated by activation of extracellular-regulated kinase 1/2 and repression by PKC (show PKC Antibodies).
LHbeta (show LHB Antibodies) and LH-R (show LHCGR Antibodies) mRNA expression might be involved in initial maturation events of gametes, at least in males, while the gradually increase of FSH-R (show FSHR Antibodies) mRNA coincided with the advancing process of gamete maturation in both sexes
A major regulatory mechanism for FSH (show BRD2 Antibodies) glycosylation involves control of beta-subunit (show POLG Antibodies) N-glycosylation, possibly by inhibition of oligosaccharyl transferase. Two primate species exhibited the same all-or-none pattern of pituitary FSHbeta glycosylation.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb (show LHB Antibodies)), follicle stimulating hormone beta (Fshb), and intracellular adhesion molecule (show NCAM1 Antibodies)-5 (Icam5 (show ICAM5 Antibodies)) in females but only decreased expression of Icam5 (show ICAM5 Antibodies) in males.
GnRH (show GNRH1 Antibodies) stimulation of Fshb expression is dependent on miR (show MLXIP Antibodies)-132/212 and involves a SIRT1 (show SIRT1 Antibodies)-FOXO1 (show FOXO1 Antibodies) pathway.
results suggest that FOXO1 (show FOXO1 Antibodies) binding to the proximal Fshb promoter as well as FOXO1 (show FOXO1 Antibodies) interaction with SMAD3 (show SMAD3 Antibodies)/4 proteins may result in decreased activin (show Actbeta Antibodies) induction of Fshb in gonadotropes
SCGB3A2 (show SCGB3A2 Antibodies) regulates FSH (show BRD2 Antibodies)/LH production in the anterior pituitary lobe.
Data suggest that the BMP2 (show BMP2 Antibodies)-like Activin A (show INHBA Antibodies)/BMP2 (show BMP2 Antibodies) chimera AB215 regulates follicle stimulating hormone beta (FSHbeta) induction in LbetaT2 gonadotroph cells due to its ability to block activin A (show INHBA Antibodies) signaling.
Two regions of the proximal Fshb promoter (-50/-41 and -30/-21) appear to be necessary for FOXO1 (show FOXO1 Antibodies) suppression of GnRH (show GNRH1 Antibodies)-induced Fshb transcription.
Data suggest BMP2 (bone morphogenetic protein 2 (show BMP2 Antibodies)) stimulates SMAD2 (show SMAD2 Antibodies)/3 signaling in gonadotrophs via Bmpr1a (bone morphogenetic protein receptor type 1A (show BMPR1A Antibodies)); such signaling via SMAD3 (show SMAD3 Antibodies) appears to be necessary for up-regulation of Fshb transcription.
The activin A (show INHBA Antibodies) signals via SMAD (show SMAD1 Antibodies) proteins, but not TAK1 (show NR2C2 Antibodies) or p38 (show CRK Antibodies), to regulate murine and ovine Fshb transcription in gonadotrope-like cells.
The insulin (show INS Antibodies)/IGF signaling pathway is required for FSH (show BRD2 Antibodies)-mediated Sertoli cell proliferation.
FOXL2 (show FOXL2 Antibodies) is required for FSH (show BRD2 Antibodies) synthesis in vivo.
The FSHB -211G>T variant attenuates serum FSH (show BRD2 Antibodies) levels in the supraphysiological gonadotropin setting of Klinefelter syndrome
3 known FSH-action modulating SNPs (FSHB -211G/T; FSHR -29G/A, c.2039 A/G)explained together 2.3%, 1.4%, 1.0 and 1.1% of the measured variance in serum FSH, Inhibin B, testosterone and total testes volume, respectively.
The combined effect of FSHB GG+FSHR (show FSHR Antibodies) AA may potentiate the FSH (show BRD2 Antibodies) pathway, which increases serum levels of FSH (show BRD2 Antibodies) and reduces antimullerian hormone in health girls.
Serum FSH (show BRD2 Antibodies) levels are affected by the combination of genetic polymorphisms in FSHR (show FSHR Antibodies) and FSHB
Data suggest that low serum FSH (show BRD2 Antibodies) levels in men with an SNP in promoter region of FSHB (-211G/T) result from reduced binding of LHX3 (LIM homeobox 3 (show LHX3 Antibodies)) to FSHB promoter/response element and down-regulation of FSHB transcription in gonadotrophs.
activin (show Actbeta Antibodies)-regulated transcription mediated by forkhead box L2 (show FOXL2 Antibodies) [review]
Data indicate that neither serum inhibin B nor follicle-stimulating hormone (FSH (show BRD2 Antibodies)) is a suitable surrogate for determination of sperm concentration in a semen sample.
Ser680 genotype for FSHR (show FSHR Antibodies) is a factor of relative resistance to FSH (show BRD2 Antibodies) stimulation resulting in slightly higher FSH (show BRD2 Antibodies) serum levels, thus leading to a prolonged duration of the menstrual cycle.
Phenotypic consequences of FSHB -211G-->T on the hypothalamic-pituitary-ovarian axis in women.
Both estradiol and progesterone uniquely modulate basal and GnRH-stimulated gonadotropin promoters without affecting cell growth.
Study describes generation and characterization of a new Fshb-iCre deleter strain using 4.7 kb of ovine Fshb promoter sequences driving iCre expression exclusively in the gonadotrope lineage with mice developing normally, and fertile.
the novel cis (show CISH Antibodies)-regulatory element generated by the c.-1539_-1538delGGinsTTAACT mutations might play an important role in repressing FSHB transcription, possibly leading to reduced fertility
A 200-base region in the bovine FSHbeta 3' untranslated region downregulates reporter expression at the translational level via interactions between AREs in both the 3'UTR (show UTS2R Antibodies) and transfactors.
The shift in FSH (show BRD2 Antibodies) isoforms toward a greater abundance of the less acidic isoforms appears to be a key component in determining the capability for producing a preovulatory rise in estradiol.
The effect of a single nucleotide polymorphism of the follicle stimulating hormone beta chain on bull fertility and semen quality is reported.
As in vitro experiments in the present study suggested that LHX2 (show LHX2 Antibodies) regulated the expression of Fshbeta, it is possible that LHX2 (show LHX2 Antibodies) controls FSH (show BRD2 Antibodies) synthesis at the transcriptional level.
Results showed that the effects of FSHb, ESR (show ESR1 Antibodies), and PRLR (show PRLR Antibodies) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
LHX3 (show LHX3 Antibodies) LIM homeodomain (show LHX2 Antibodies) transcription factor is involved in activation of the FSH beta-subunit (show POLG Antibodies) gene in the pituitary gonadotrope cell.
Prop-1 (show PROP1 Antibodies) participates in the regulation of FSHbeta gene
A allele of FSHbeta-1 locus in all the population and FSHbeta-2 locus in pigs of the first parity had the positive effective on TNB, NBA, and WB.
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.
, Gth I
, follicle-stimulating hormone beta subunit
, follitropin subunit beta
, FSH beta
, follcle-stimulating hormone beta subunit
, follicle stimulating hormone, beta polypeptide
, follitropin beta chain
, Follicle-stimulating hormone beta subunit
, follicle stimulating hormone beta-subunit
, follitropin, beta chain
, follicle - stimulating hormone subunit beta
, follicle stimulating hormone beta
, follicle-stimulating hormone beta-subunit
, follicle-stimulating hormone subunit beta
, class 1 follicle-stimulating hormone beta polypeptide
, class 2 follicle-stimulating hormone beta polypeptide
, follicule stimulating hormone, beta polypeptide
, follicle stimulating hormone beta subunit
, follitropin beta subunit