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FMNL2 encodes a formin-related protein. Additionally we are shipping FMNL2 Antibodies (22) and FMNL2 Kits (2) and many more products for this protein.
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miR (show MLXIP Proteins)-206 functioned as a tumor suppressor in the progression of colorectal cancer(CRC (show CALR Proteins)) by targeting FMNL2 and c-MET. Restoration of miR (show MLXIP Proteins)-206 expression may represent a promising therapeutic approach for targeting malignant CRC (show CALR Proteins).
Capping protein and FMNL2 functionally coregulate filament barbed-end assembly.
The two interacting FMNL-Cdc42 heterodimers expose six membrane interaction motifs on a convex protein surface, the assembly of which may facilitate actin filament elongation at the leading edge of lamellipodia and filopodia.
FMNL2, acting as upstream of RhoA by interacting with LARG, can promote actin assembly and colorectal carcinoma cell invasion through a Rho/ROCK-dependent mechanism.
These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness.
MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5.
Rac1-induced actin assembly and subsequent AJ formation critically depends on FMNL2.
miR (show MLXIP Proteins)-137, induced by its upstream transcription factor HMGA1 (show HMGA1 Proteins), can suppress colorectal cancer cell invasion and metastasis by targeting FMNL2.
Protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3 (show FMNL3 Proteins).
FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia.
FMNL1 (show FMNL1 Proteins) and FMNL2 are required non-redundantly in the repair of damaged myofibrils.
mDia1-FH2 has an effect on the conformation of actin filaments
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.
, formin homology 2 domain containing 2
, formin homology 2 domain-containing protein 2
, formin-like protein 2
, formin-like domain containing protein MAN
, protein Man