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Formyl Peptide Receptor 1 Proteins (FPR1)

FPR1 encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. Additionally we are shipping FPR1 Antibodies (85) and FPR1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FPR1 2357 P21462
FPR1 14293 P33766
Rat FPR1 FPR1 292409  
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Top FPR1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

FPR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Formyl Peptide Receptor 1 (FPR1) Interaction Partners

Human Formyl Peptide Receptor 1 (FPR1) interaction partners

  1. FAM19A4 (show FAM19A4 Proteins) is a novel ligand of formyl peptide receptor 1.

  2. The authors describe here the activation of isolated human blood neutrophils by TcdB and, moreover, by toxin fragments generated by limited proteolytical digestion via the FPR1 receptor.

  3. these results highlight the importance of FPR1 in chemotherapy-induced anticancer immune responses.

  4. Data suggest that formyl peptide receptor 1 (FPR1) stimulation may represent a novel therapeutic approach to counteract tumor angiogenesis.

  5. a pepducin designed to target FPR1 was found to hijack FPR2 (show FPR2 Proteins) and potently inhibit neutrophil functions

  6. the co-upregulated expression of mast cell chymase (show CMA1 Proteins) and ANXA1 (show ANXA1 Proteins)-FPR1 system in ectopic endometrium suggests their involvement in the development of endometriotic lesions.

  7. FPR1 rs78488639 interacted with CFH (show CFH Proteins) rs800292, HTRA1 (show HTRA1 Proteins) rs11200638, and smoking, enhancing risk to exudative age-related macular degeneration and polypoidal choroidal vasculopathy .

  8. These results demonstrate that a necroptosis pathway, likely mediated by annexin 1 (show ANXA1 Proteins) acting through the FPR1 receptor, contributes to Stevens-Johnson syndrome (SJS (show HSPG2 Proteins)) and toxic epidermal necrolysis.

  9. A low FPR1/beta1 integrin co-localization was observed.

  10. cross-desensitization of CCR1 by FPR1 was associated with CCR1 phosphorylation and moderate reduction of CCR1 cell-surface expression. In contrast, CCR2 (show CCR2 Proteins) was not phosphorylated or internalized after FPR1 activation.

Mouse (Murine) Formyl Peptide Receptor 1 (FPR1) interaction partners

  1. Blocking of FPR1 completely abrogated the fMet-Leu-Phe-, gliadin- and synthetic peptide-induced migration.

  2. these results highlight the importance of FPR1 in chemotherapy-induced anticancer immune responses.

  3. Ovalbumininduced airway inflammation is mediated by upregulation of the TLR2/MyD88 (show MYD88 Proteins)/NFkappaB signaling pathway and inhibition of LXA4R.

  4. Deficiency of formyl peptide receptor 1 is associated with increased inflammation and enhanced liver injury after LPS (show TLR4 Proteins)-stimulation

  5. Fpr1/2 are critical for normal healing of the sterile skin wound by mediating the first wave of neutrophil infiltration.

  6. these findings identify a novel role of FPR1 as pattern recognition receptors for perceiving the enteric microbiota that promotes repair of mucosal wounds via generation of reactive oxygen species from the enterocyte NOX1 (show NOX1 Proteins).

  7. FPR1 and FPR2 (show FPR2 Proteins) play an important role in the innate immune responses against Streptococcus pneumoniae within the central nervous system and the lack of the receptors leads to a dysregulation of the inflammatory response compared with wild-type mice.

  8. Further, these results reveal Fpr1 as a major mediator of host commensal interaction during dysbiosis.

  9. The mechanism involved impaired early neutrophil recruitment to the liver with Fpr1 being sole receptor for neutrophils to sense Listeria chemoattractant signals and for production of bactericidal superoxide.

  10. findings may have clinical significance because current smokers and subjects with emphysema showed increased FPR expression in bronchoalveolar fluids and on peripheral neutrophils

FPR1 Protein Profile

Protein Summary

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.

Gene names and symbols associated with FPR1

  • formyl peptide receptor 1 (FPR1)
  • formyl peptide receptor 1 (Fpr1)
  • N-formyl peptide receptor (FPR)
  • fMLF-R protein
  • FMLP protein
  • FPR protein
  • FPR1 protein
  • LXA4R protein

Protein level used designations for FPR1

N-formylpeptide chemoattractant receptor , fMLP receptor , fMet-Leu-Phe receptor , N-formyl peptide receptor , lipoxin A4 receptor

GENE ID SPECIES
2357 Homo sapiens
14293 Mus musculus
292409 Rattus norvegicus
456254 Pan troglodytes
100443662 Pongo abelii
100009153 Oryctolagus cuniculus
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