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The protein encoded by FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. Additionally we are shipping FXR1 Antibodies (96) and many more products for this protein.
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FXR1P is a GSK3beta substrate with a role in regulating mood and emotion processing
Removal of FXR1P from the forebrain of postnatal mice selectively enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP (show SCP2 Proteins)), and de novo GluA2 (show GRIA2 Proteins) synthesis.
FXR1P was highly expressed during hippocampal development and co-localized with ribosomes and mRNAs in the dendrite and at a subset of spines.
FXR1P is required for efficient processing of pre-microR-9 and pre-microR-124 in vitro and forms a complex with Dicer (show DICER1 Proteins) and pre-miRNAs.
Fxr1 knockout hearts exhibit an up-regulation of desmoplakin and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
Targeting the p38 mitogen-activated protein kinase (show MAPK14 Proteins) pathway of LPS (show TLR4 Proteins)-treated cells with small molecule inhibitors can induce FXR1 protein expression.
Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated (show NSDHL Proteins) muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids.
FXR1P operates as a repressor of TNF (show TNF Proteins) translation
the data clearly demonstrate the importance of FXR1P RBP (show RBP4 Proteins) in the regulation of a wide spectrum of inflammatory genes and suggest an important role of MAP signalling in the response of macrophages to selected TLR ligands, including CpG.
Fxr1 regulates mammalian circadian behavioral rhythms.
Fxr1 plays a vital role during Xenopus embryogenesis. Knockdown of Fxr1 has highly muscle-specific (show EIF3K Proteins) effects leading to disruption of MyoD (show MYOD1 Proteins) expression, inhibition of somite myotomal cell rotation and segmentation, and abnormal dermatome formation.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Proteins) target genes Fgf15 and Shp (show LAMC1 Proteins) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Proteins) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
These data reveal a new role of FXR1 in controlling induction of monocyte migration.
FXR1 binds and destabilizes p21 (show CDKN1A Proteins) mRNA, binds and stabilizes TERC RNA and suppresses the cellular senescence in oral cancer cells.
FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.
P97 (show EIF4G2 Proteins) interacts with 3' UTR-binding FXR1a-associated microRNPs and with PARN (show PARN Proteins), which binds mRNA 5' caps (show CAPS Proteins), forming a specialized complex to translate recruited mRNAs in these altered canonical translation conditions.
An accumulation of 8 SNPs in the fragile gene family (FMR1 (show FMR1 Proteins), FXR1 and FXR2 (show FXR2 Proteins))were found associated with autistic traits in a sample of male patients.
The mechanisms by which FXR1 executes its regulatory function by forming a novel complex with two other oncogenes, protein kinase C, iota and epithelial cell transforming 2, located in the same amplicon via distinct binding mechanisms, were identified.
binding of PKP1/3 to FXR1 was RNA independent, and both PKP3 and FXR1 stabilized PKP2 mRNA.
Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A (show LMNA Proteins) p.R482W mutation elicits a myogenic gene expression program in preadipocytes.
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
Fragile X mental retardation syndrome-related protein 1 homolog
, fragile X mental retardation syndrome-related protein 1 homolog
, fragile X mental retardation syndrome-related protein 1
, fragile X mental retardation, autosomal homolog 1
, fragile X mental retardation-related protein 1
, fragile X mental retardation syndrome-related protein 1-like
, fragile X mental retardation gene, autosomal homolog
, fragile-X-related protein 1
, fragile X-related protein
, fragile X mental retardation syndrome-related protein 1 homolog A
, fragile X mental retardation gene 1, autosomal homolog