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The protein encoded by FXR2 is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. Additionally we are shipping Fragile X Mental Retardation, Autosomal Homolog 2 Antibodies (83) and many more products for this protein.
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An accumulation of 8 SNPs in the fragile gene family (FMR1 (show FMR1 Proteins), FXR1 (show FXR1 Proteins) and FXR2)were found associated with autistic traits in a sample of male patients.
Data show that the nuclear localization signals of the FXR1 (show FXR1 Proteins) and FXR2 comprise tandem Tudor domain architectures.
These results indicate that FMR1 (show FMR1 Proteins) gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 (show FXR1 Proteins) or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.
FXR1P (show FXR1 Proteins) and FXR2P KH2 (show KCNG1 Proteins) domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP (show FMR1 Proteins) KH2 (show KCNG1 Proteins) domain.
Both Fmr1 (show FMR1 Proteins) and Fxr2 knockout mice have reduced fat deposits and glucose metabolism.
these findings show a coordinated regulation of PSD95/Dlg4 (show DLG4 Proteins) mRNA by FMRP (show FMR1 Proteins) and FXR2P that ultimately affects its fine-tuning during synaptic activity.
Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal.
Findings suggest that Fmr1 (show FMR1 Proteins) and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes.
Fxr2 regulates mammalian circadian behavioral rhythms.
to unravel the function of Fxr2 protein, the expression pattern of 12,588 genes was studied in the brains of wild-type and Fxr2 knockout mice; genes and gene groups de-regulated in the brains of Fxr2 knockout mice were identified
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.
fragile X mental retardation syndrome-related protein 2
, fragile X mental retardation syndrome related protein 2
, fragile X mental retardation, autosomal homolog 2
, fragile X mental retardation syndrome-related protein 2-like
, fragile X-mental retardation 1-like 2
, fragile X mental retardation gene 2, autosomal homolog
, fragile X mental retardation-related protein 2