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A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Additionally we are shipping FN3KRP Antibodies (22) and FN3KRP Kits (2) and many more products for this protein.
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Human FN3KRP Protein expressed in Escherichia coli (E. coli) - ABIN1098738
Collard, Wiame, Bergans, Fortpied, Vertommen, Vanstapel, Delpierre, Van Schaftingen: Fructosamine 3-kinase-related protein and deglycation in human erythrocytes. in The Biochemical journal 2004
Show all 2 references for ABIN1098738
These data suggest that FN3K (show FN3K Proteins) and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state.
In this paper we propose a resolution of both these quandaries by proposing that fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by FN3KRP and/or possibly FN3K (show FN3K Proteins).
FN3KRP phosphorylates meglumine to produce meglumine-4-phosphate.
Studies provide evidence that Fn3KRP possesses an ATP-binding domain that is structurally related to that of both the aminoglycoside kinases and eukaryotic protein kinases.
fructosamine 3-kinase (show FN3K Proteins) and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants.
, fructosamine-3-kinase-related protein
, fructosamine 3 kinase related protein
, putative fructosamine-3-kinase-related protein
, FN3K-related protein
, fructosamine 3-kinase-related protein
, ortholog of human fructosamine-3-kinase-related protein FN3KRP