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anti-Fumarate Hydratase (FH) Antibodies

The protein encoded by FH is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. Additionally we are shipping FH Kits (22) and FH Proteins (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FH 2271 P07954
FH 24368  
FH 14194 P97807
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Top anti-FH Antibodies at antibodies-online.com

Showing 10 out of 143 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN190758 (0.01µg/ml) staining of Human Kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated WB FH monoclonal antibody (M09), clone 3E7 Western Blot analysis of FH expression in HeLa on formalin-fixed paraffin-embedded human seminoma (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to FH on HeLa cell (antibody concentration 10 µg/mL). FH monoclonal antibody (M07), clone 5C12 Western Blot analysis of FH expression in HeLa. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated WB FH Antibody (N-term)(Ascites) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the FH antibody detected the FH protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB FH Antibody (N-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the FH  Antibody detected the FH  protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Dog Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated ELISA, WB FH monoclonal antibody (M01), clone 2E10. Western Blot analysis of FH expression in HeLa . Detection limit for recombinant GST tagged FH is approximately 3ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IP, ELISA, WB 100 μg Log in to see 16 Days
$218.90
Details
Human Mouse Un-conjugated IF, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FH (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FH. Western blot analysis of extracts (35 µg) from 9 different cell lines by using anti-FH monoclonal antibody. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Immunohistochemical staining of paraffin-embedded colon tissue using anti-FHmouse monoclonal antibody. (ABIN2452568, Dilution 1:50) Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-FHmouse monoclonal antibody. (ABIN2452568, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details

FH Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FH Antibodies

  1. Human Monoclonal FH Primary Antibody for WB - ABIN393935 : Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010 (PubMed)
    Show all 5 references for ABIN393935

  2. Human Monoclonal FH Primary Antibody for IF, WB - ABIN394387 : Yogev, Yogev, Singer, Shaulian, Goldberg, Fox, Pines: Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. in PLoS biology 2010 (PubMed)
    Show all 5 references for ABIN394387

  3. Human Monoclonal FH Primary Antibody for ELISA, WB - ABIN515646 : Kov?ová, Mrá?ek, N?sková, Holzerová, Vrbacký, Pecina, Hejzlarová, K?u?ková, Rohlena, Neuzil, Houšt?k: High molecular weight forms of mammalian respiratory chain complex II. in PLoS ONE 2013 (PubMed)
    Show all 2 references for ABIN515646

  4. Human Polyclonal FH Primary Antibody for ELISA, WB - ABIN190758 : Pollard, Spencer-Dene, Shukla, Howarth, Nye, El-Bahrawy, Deheragoda, Joannou, McDonald, Martin, Igarashi, Varsani-Brown, Rosewell, Poulsom, Maxwell, Stamp, Tomlinson: Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. in Cancer cell 2007 (PubMed)

More Antibodies against FH Interaction Partners

Human Fumarate Hydratase (FH) interaction partners

  1. A novel deletion of the Fumarate Hydratase (FH) gene was identified in a 22 year old male and his father, which predisposes to an aggressive form of renal cell cancer.

  2. While the great majority of patients with hereditary leiomyomatosis and renal cell carcinoma (show MOK Antibodies) will have FH-deficient leiomyomas, 1% of all uterine leiomyomas are FH deficient usually due to somatic inactivation.

  3. significant association with overall survival were confirmed for SDHC (show SDHC Antibodies) gene, SDHD (show SDHD Antibodies) gene and FH gene ... SDHC (show SDHC Antibodies) gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma

  4. Describe a novel mutation in the fumarate hydratase gene in a family with atypical uterine leiomyomas and hereditary leiomyomatosis and renal cell cancer.

  5. Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval

  6. Morphology and immunohistochemistry for fumarate hydratase aid in detection of fumarate hydratase mutations in uterine leiomyomas from young patients.

  7. Case report of a family with a fumarate hydratase mutation causing uterine leiomyomas and renal cell cancer.

  8. A multiplex snapback primer system was developed for the simultaneous detection of JAK2 (show JAK2 Antibodies) V617F and MPL (show MPL Antibodies) W515L/K mutations in Philadelphia chromosome- (Ph-) negative myeloproliferative neoplasms (MPNs).

  9. Novel missense mutation has been found in the fumarate hydratase gene in familial renal cell cancer patients lacking cutaneous leiomyomas.

  10. These results extend the range of clinical and biochemical variation associated with fumarase deficiency.

Mouse (Murine) Fumarate Hydratase (FH) interaction partners

  1. Reexpression of cytosolic FH in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway.

  2. Tumor-derived FH and SDH (show SDS Antibodies) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Antibodies).

  3. identification of a metabolic pathway that is induced in Fh1-deficient cells to demonstrate that inhibition of haem oxygenation is synthetically lethal when combined with Fh1 deficiency, providing a new potential target for treating HLRCC patients

  4. These experiments demonstrated that upregulation of HIF-1alpha (show HIF1A Antibodies) occurs as a direct consequence of FH inactivation.

  5. progression of tumors where FH is lost might be boosted by activation of the MET oncogene (show RAB1A Antibodies), which is able to drive cell-autonomous tumor progression

FH Antigen Profile

Protein Summary

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Gene names and symbols associated with anti-Fumarate Hydratase (FH) Antibodies

  • fumarate hydratase (FH) antibody
  • fumarate hydratase (fumH) antibody
  • fumarate hydratase (Fh) antibody
  • fumarate hydratase (fh) antibody
  • fumarate hydratase 1 (Fh1) antibody
  • DDBDRAFT_0205237 antibody
  • DDBDRAFT_0231397 antibody
  • DDBDRAFT_0231400 antibody
  • DDB_0205237 antibody
  • DDB_0231397 antibody
  • DDB_0231400 antibody
  • Fh antibody
  • Fh-1 antibody
  • Fh1 antibody
  • HLRCC antibody
  • im:7152785 antibody
  • LRCC antibody
  • MCL antibody
  • MCUL1 antibody
  • ns:zf-e152 antibody
  • zf-e152 antibody
  • zgc:66253 antibody
  • zgc:77498 antibody

Protein level used designations for anti-Fumarate Hydratase (FH) Antibodies

fumarate hydratase, mitochondrial , fumarate hydratase , fumarase , fumarate hydratase 1 , EF-3

GENE ID SPECIES
100302102 Ovis aries
100060381 Equus caballus
707542 Macaca mulatta
420969 Gallus gallus
457851 Pan troglodytes
100172452 Pongo abelii
8622588 Dictyostelium discoideum AX4
2271 Homo sapiens
24368 Rattus norvegicus
480092 Canis lupus familiaris
100627128 Sus scrofa
520260 Bos taurus
393938 Danio rerio
14194 Mus musculus
Selected quality suppliers for anti-FH (FH) Antibodies
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