FH Products
(Fumarate Hydratase (FH))
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The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008].
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Featured FH Categories
FH Antibodies
High quality antibodies with extensive validation data.
FH ELISA Kits
Reliable ELISA kits for a wide range of species.
FH Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FH Antibodies
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Reactivity
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Reactivity
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Cat. No.
ABIN7444424
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Cat. No.
ABIN2856710
Quantity
100 μL
Datasheet
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Reactivity
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ABIN1498267
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Recommended FH ELISA Kits
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ABIN6966911
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Rabbit
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Validations
Cat. No.
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96 tests
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Pig
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10 μg
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Cat. No.
ABIN3080328
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Reactivity
Mouse
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Latest Publications for our FH products
: "Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor." in: Cell death discovery, Vol. 4, pp. 18, (2018) (PubMed).: "Fumarase-deficient Uterine Leiomyomas: An Immunohistochemical, Molecular Genetic, and Clinicopathologic Study of 86 Cases." in: The American journal of surgical pathology, Vol. 40, Issue 12, pp. 1661-1669, (2017) (PubMed).
: "Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function." in: Scientific reports, Vol. 6, pp. 22788, (2016) (PubMed).
: "Differential proteomic expression of human placenta and fetal development following e-waste lead and cadmium exposure in utero." in: The Science of the total environment, Vol. 550, pp. 1163-1170, (2016) (PubMed).
: "Mitochondrial membrane assembly of TMEM70 protein." in: Mitochondrion, Vol. 15, pp. 1-9, (2014) (PubMed).
: "High molecular weight forms of mammalian respiratory chain complex II." in: PLoS ONE, Vol. 8, Issue 8, pp. e71869, (2013) (PubMed).
: "Alterations in the mitochondrial proteome of neuroblastoma cells in response to complex 1 inhibition." in: Journal of proteome research, Vol. 10, Issue 4, pp. 1974-86, (2011) (PubMed).
: "Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway." in: Cancer cell, Vol. 11, Issue 4, pp. 311-9, (2007) (PubMed).
Synonyms and alternative names related to FH
fumarate hydratase (FH), fumarate hydratase (fumH), fumarate hydratase (Fh), fumarate hydratase (fh), fumarate hydratase 1 (Fh1), DDBDRAFT_0205237, DDBDRAFT_0231397, DDBDRAFT_0231400, DDB_0205237, DDB_0231397, DDB_0231400, FH, Fh, Fh-1, Fh1, HLRCC, im:7152785, LRCC, MCL, MCUL1, ns:zf-e152, zf-e152, zgc:66253, zgc:77498Protein level used designations for FH
- fumarate hydratase, mitochondrial
- fumarate hydratase
- fumarase
- fumarate hydratase 1
- EF-3
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