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G Protein-Coupled Receptor Kinase 1 Proteins (GRK1)

Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity).. Additionally we are shipping G Protein-Coupled Receptor Kinase 1 Antibodies (95) and G Protein-Coupled Receptor Kinase 1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRK1 6011 Q15835
GRK1 24013  
Rat GRK1 GRK1 81760 Q63651
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Top G Protein-Coupled Receptor Kinase 1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GRK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for G Protein-Coupled Receptor Kinase 1 (GRK1) Interaction Partners

Human G Protein-Coupled Receptor Kinase 1 (GRK1) interaction partners

  1. AAMP (show AAMP Proteins) Regulates Endothelial Cell Migration and Angiogenesis Through RhoA (show RHOA Proteins)/Rho Kinase (show ROCK1 Proteins) Signaling.

  2. In the Ca(2 (show CA2 Proteins)+)/NCS-1 (show NCS1 Proteins).D2R (show DRD2 Proteins) peptide complex, the C-terminal region adopts a 310 helix-turn-310 helix, whereas in the GRK1 peptide complex it forms an a-helix

  3. Rho-kinase (show ROCK1 Proteins) activity exhibits distinct circadian variation associated with alterations in coronary vasomotor responses and autonomic activity in VSA patients.

  4. The selective thinning of the inner retinal layers in patients with GRM6 (show GRM6 Proteins) mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina.

  5. Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation.

  6. There are two genes that cause Oguchi disease: the G protein-coupled receptor kinase 1 gene and the S antigen (show SAG Proteins) gene. There is evidence that Oguchi disease and retinitis pigmentosa (RP) can coexist in the same family or even in the same individual

  7. Phosphorylation of GRK1 and GRK7 by PKA occurs in the dark, when cAMP levels in photoreceptor cells are elevated.

  8. The disease in the Pakistani family localizes to 13q34 and is caused by a novel deletion including Exon 3 of the GRK1 gene.

  9. G protein-coupled receptor kinase site serine cluster has a role in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation

  10. RhoK activation in brain microvascular endothelial cells could be a cause of blood-brain barrier impairment during HIV-1 encephalitis.

Cow (Bovine) G Protein-Coupled Receptor Kinase 1 (GRK1) interaction partners

  1. The C-terminal segment in GCAP2 (show GUCA1B Proteins) confers target selectivity, facilitates membrane binding and provides sensitivity of the membrane localization of the protein to phosphorylation by rhodopsin kinase.

  2. The methylation status of GRK1 is affected by nucleotide binding and by the levels of free Ca2 (show CA2 Proteins) + via recoverin (show RCVRN Proteins).

  3. crystalline dimer interface was disrupted with a L166K mutation and the structure of GRK1-L166K was determined in complex with Mg(2 (show MCOLN1 Proteins)+) . ATP to 2.5 A resolution

  4. A novel rhodopsin-kinase-binding site within the C-terminal region of recoverin (show RCVRN Proteins).

  5. similar to transducin activation, rhodopsin phosphorylation by GRK1 and high affinity arrestin-1 binding only requires a rhodopsin monomer

  6. Recoverin (show RCVRN Proteins) and rhodopsin kinase have roles in a Ca2 (show CA2 Proteins)+-dependent feedback loop in membrane rafts from rod outer segments

  7. an interaction surface for the recoverin (show RCVRN Proteins) target rhodopsin kinase is constituted upon Ca2 (show CA2 Proteins)+ binding to the non-acylated mutant

  8. Recoverin (show RCVRN Proteins) binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase

  9. Ca(2 (show CA2 Proteins)+)-bound recoverin (show RCVRN Proteins) is bound between rhodopsin and RK in a ternary complex on rod outer segment disk membranes, thereby blocking RK interaction with rhodopsin at high Ca(2 (show CA2 Proteins)+)

  10. key elements of rhodopsin kinase in different ligand states are involved in G protein-coupled receptor (show GPBAR1 Proteins) kinase activation

Mouse (Murine) G Protein-Coupled Receptor Kinase 1 (GRK1) interaction partners

  1. The retinal phenotype of Grk1-/- mice is compromised by a Crb1 (show CRB1 Proteins) rd8 mutation.

  2. Rods and cones share the same isoforms of recoverin (show RCVRN Proteins) and GRK1, and photoactivation also triggers a calcium decline in cones

  3. Knockout of Unc119 (show UNC119 Proteins) partially reversed the transport defect of GRK1 in cone photoreceptors caused by deletion of Pde6d (show PDE6D Proteins).

  4. rhodopsin kinase may modulate the decay of light-activated PDE (show TWIST1 Proteins)*, which may be responsible for the quickening of response recovery in background light.

  5. Altering the expression of GRK1 from 0.3- to 3-fold that in wild-type rods had little effect on the single photon response amplitude.

  6. phototransduction does not play a direct role in the light-dependent dephosphorylation of GRK1.

  7. PLCdelta3 negatively regulates RhoA (show RHOA Proteins) expression, inhibits RhoA (show RHOA Proteins)/Rho kinase (show ROCK2 Proteins) signaling, and thereby promotes neurite extension.

  8. The results of this study demonstrated a light-independent mechanism for retinal degeneration in the absence of GRK1, suggesting a second, not previously recognized role for that kinase.

  9. Nrl (show NRL Proteins) and Grk1 have roles in photoresponse recovery and age-related degeneration

  10. transport of prenylated proteins, particularly GRK1 and cone phosphodiesterase, to rod and cone outer segments

G Protein-Coupled Receptor Kinase 1 (GRK1) Protein Profile

Protein Summary

Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity).

Gene names and symbols associated with GRK1

  • G protein-coupled receptor kinase 1 (Gprk1)
  • G protein-coupled receptor kinase 1 a (grk1a)
  • G protein-coupled receptor kinase 1 (GRK1)
  • G protein-coupled receptor kinase 1 (Grk1)
  • CG40129 protein
  • CT4320 protein
  • Dmel\\CG40129 protein
  • Gprk-1 protein
  • Gprk1 protein
  • grk1 protein
  • Rhok protein
  • Rk protein
  • Rok protein

Protein level used designations for GRK1

CG40129-PA , CG40129-PB , Gprk1-PA , Gprk1-PB , rhodopsin kinase , G-protein-coupled receptor kinase 1a , G-protein coupled receptor kinase 1 , RK , G-protein receptor kinase 1 , G protein-coupled receptpr kinase 1

GENE ID SPECIES
3355013 Drosophila melanogaster
564152 Danio rerio
395431 Gallus gallus
6011 Homo sapiens
281457 Bos taurus
24013 Mus musculus
81760 Rattus norvegicus
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