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GLIS2 is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. Additionally we are shipping GLIS2 Proteins (4) and many more products for this protein.
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Cow (Bovine) Polyclonal GLIS2 Primary Antibody for IHC, WB - ABIN2779249
Zhang, Nakanishi, Kurebayashi, Yoshino, Perantoni, Kim, Jetten: Characterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
CBFA2T3 (show CBFA2T3 Antibodies)-GLIS2 fusion is associated with acute megakaryoblastic leukemia in non-Down syndrome.
specific interference with ETO2 (show CBFA2T3 Antibodies)-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.
Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary.
Nephronophthisis 7-related mutation C175R affects both localization and function of GLIS2 protein.
Glis2/NPHP7 is extensively modified by post-translational modifications
Findings are unprecedented and indicate that the DHH (show DHH Antibodies)-RHEBL1 (show RHEBL1 Antibodies) fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3 (show CBFA2T3 Antibodies)-GLIS2-positive childhood AML (show RUNX1 Antibodies).
BBS11 (show TRIM32 Antibodies) promotes accumulation of NPHP7, changing the properties of NPHP7. TRIM32 (show TRIM32 Antibodies) Modulates the Transcriptional Activities of Glis2
Recessive mutation in GLIS2 gene is associated with Caroli disease.
Identification of a cryptic chromosome 16 inversion (inv (show INVS Antibodies)(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3 (show CBFA2T3 Antibodies)-GLIS2 fusion protein.
Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity
Kif3a (show KIF3A Antibodies) is required for cell cycle regulation and the DNA damage response, whereas cell senescence is significantly enhanced in Glis2 null cells.
Characterization of Glis2, a novel gene encoding a Gli (show GLI1 Antibodies)-related, Kruppel-like transcription factor (show KLF4 Antibodies) with transactivation and repressor functions
Deficiency in Glis2 expression leads to tubular atrophy & progressive fibrosis, similar to nephronophthisis, that ultimately results in renal failure. Glis2 plays a critical role in the maintenance of normal kidney architecture and functions.
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.
Kruppel-like zinc finger protein GLIS2
, Gli-Kruppel zinc-finger protein NKL
, GLI-similar 2
, GLI-similar protein 2
, neuronal Krueppel-like protein
, zinc finger protein GLIS2
, GLI-Kruppel family member GLI5
, Kruppel-like factor 16 (neuronal)
, zinc finger protein GLI5
, GLIS family zinc finger 2